Abcb1b ATP-binding cassette, sub-family B member 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcb1bprovided by RGD
Official Full Name: ATP-binding cassette, sub-family B member 1Bprovided by RGD
Primary source: RGD:3318
See related: Ensembl:ENSRNOG00000066042 AllianceGenome:RGD:3318
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mdr1; Pgy1; Pgy2; Abcb1; mdr1b
Summary: Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including Sertoli cell barrier remodeling; animal organ development; and cellular response to external biotic stimulus. Located in Golgi membrane and external side of apical plasma membrane. Used to study brain disease (multiple); colorectal adenocarcinoma; end stage renal disease; and human immunodeficiency virus infectious disease. Biomarker of brain disease (multiple); cholestasis; human immunodeficiency virus infectious disease; non-alcoholic fatty liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 125.5), Liver (RPKM 79.4) and 6 other tissues See more
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Genomic context

Location:: 4q12

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (26197706..26280156, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (25242761..25325194, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (22225123..22307577, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia.
Title: Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia.
Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats.
Title: Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats.
Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins.
Title: Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins.
P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss.
Title: P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss.
Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats.
Title: Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats.
Abcb1a is critical in maintaining blood-testis barrier integrity, while Abcb1b is crucial for junction reassembly at the blood-testis barrier.
Title: Abcb1a and Abcb1b genes function differentially in blood-testis barrier dynamics in the rat.
P-glycoprotein up-regulation is due to increased PXR expression in brain from chronic epileptic animals.
Title: Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid.
conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.
Title: Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents.
focused ultrasound-induced blood-brain barrier disruption can temporarily suppress P-Glycoprotein expression in brain blood vessels
Title: Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles.
COX-2 and prostaglandin E2 are required for C1P-mediated increases in P-glycoprotein activity independent of transporter protein expression.
Title: Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (84)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables floppase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylcholine floppase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables xenobiotic transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Sertoli cell barrier remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to external biotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in ceramide translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in phospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in placenta development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to antineoplastic agent	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to genistein	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glycoside	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mycotoxin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intercellular canaliculus	IEA Inferred from Electronic Annotation more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-dependent translocase ABCB1

Names: ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-binding cassette, subfamily B (MDR/TAP), member 1B; ATP-binding cassette, subfamily B, member 1B; P-glycoprotein 1; P-glycoprotein 2/ multidrug resistance 1b; P-glycoprotein/multidrug resistance 1; multidrug resistance protein 1; phospholipid transporter ABCB1

NP_036755.3

EC 7.6.2.1

EC 7.6.2.2

XP_017447958.1

EC 7.6.2.1

EC 7.6.2.2

XP_038962980.1

EC 7.6.2.1

EC 7.6.2.2

XP_038962981.1

EC 7.6.2.1

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012623.3 → NP_036755.3 ATP-dependent translocase ABCB1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6K234, G3V9J6, Q8R427

Related

ENSRNOP00000049952.3, ENSRNOT00000047126.6

Conserved Domains (1) summary

PTZ00265
Location:54 → 1269

PTZ00265; multidrug resistance protein (mdr1); Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

26197706..26280156 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107052.2 → XP_038962980.1 ATP-dependent translocase ABCB1 isoform X1

UniProtKB/TrEMBL

Q8R427

Conserved Domains (1) summary

PTZ00265
Location:54 → 1211

PTZ00265; multidrug resistance protein (mdr1); Provisional
XM_017592469.3 → XP_017447958.1 ATP-dependent translocase ABCB1 isoform X2

UniProtKB/TrEMBL

Q8R427

Conserved Domains (3) summary

cd03249
Location:391 → 627

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:54 → 1201

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:53 → 341

ABC_membrane; ABC transporter transmembrane region
XM_039107053.2 → XP_038962981.1 ATP-dependent translocase ABCB1 isoform X3

UniProtKB/TrEMBL

D4A0Y9

Related

ENSRNOP00000038721.6

Conserved Domains (1) summary

PTZ00265
Location:11 → 1161

PTZ00265; multidrug resistance protein (mdr1); Provisional