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Acsm3 acyl-CoA synthetase medium-chain family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24763, updated on 2-May-2024

Summary

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Official Symbol
Acsm3provided by RGD
Official Full Name
acyl-CoA synthetase medium-chain family member 3provided by RGD
Primary source
RGD:62086
See related
Ensembl:ENSRNOG00000032246 AllianceGenome:RGD:62086
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sa; Sah
Summary
Predicted to enable acid-thiol ligase activity; fatty-acyl-CoA synthase activity; and propionate CoA-transferase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Used to study hypertension. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human ACSM3 (acyl-CoA synthetase medium chain family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 395.7), Liver (RPKM 225.5) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q35
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183564652..183591328)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (174133260..174159966)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189514504..189541233)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene uncharacterized LOC134483776 Neighboring gene acyl-CoA synthetase medium-chain family member 4 Neighboring gene THUMP domain containing 1 Neighboring gene ERI1 exoribonuclease family member 2 Neighboring gene RNA exonuclease 5 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene LYR motif containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation. Junková K, et al. Nutrients, 2021 Apr 25. PMID 33923085, Free PMC Article
  2. Localization of a blood pressure QTL on rat chromosome 1 using Dahl rat congenic strains. Saad Y, et al. Physiol Genomics, 1999 Nov 11. PMID 11015570
  3. Possible alternative splicing of the rat SA gene. Gu L, et al. Mamm Genome, 1995 Sep. PMID 8535086
  4. SA gene and blood pressure cosegregation using Dahl salt-sensitive rats. Harris EL, et al. Am J Hypertens, 1993 Apr. PMID 8507454
  5. Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1. Lindpaintner K, et al. J Hypertens, 1993 Jan. PMID 8094726

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation.
    Title: Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2-methylbutanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables medium-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables propionate CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables propionate CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables propionate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
acyl-coenzyme A synthetase ACSM3, mitochondrial
Names
SA hypertension-associated homolog
SA rat hypertension-associated homolog
SA rat hypertension-associated protein
butyrate--CoA ligase 3
butyryl-coenzyme A synthetase 3
middle-chain acyl-CoA synthetase 3
propionate--CoA ligase
protein SA
ssubA
NP_150234.1
XP_006230168.1
XP_038956744.1
XP_063137105.1
XP_063137107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033231.1 → NP_150234.1  acyl-coenzyme A synthetase ACSM3, mitochondrial

    See identical proteins and their annotated locations for NP_150234.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090325
    UniProtKB/Swiss-Prot
    Q62742, Q6SKG1
    UniProtKB/TrEMBL
    A0A8I6G5I9, A6I8M8
    Related
    ENSRNOP00000020039.6, ENSRNOT00000020039.7
    Conserved Domains (1) summary
    cd05928
    Location:48 → 577
    MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    183564652..183591328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230106.5 → XP_006230168.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006230168.1

    UniProtKB/TrEMBL
    A0A8I6G5I9
    Conserved Domains (2) summary
    COG0365
    Location:45 → 575
    Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
    cl17068
    Location:48 → 578
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_063281037.1 → XP_063137107.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X4

  3. XM_039100816.2 → XP_038956744.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I6G5I9
    Conserved Domains (1) summary
    cd05928
    Location:41 → 571
    MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

  4. XM_063281035.1 → XP_063137105.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6SKG1.1 GenPept UniProtKB/Swiss-Prot:Q6SKG1

Gene LinkOut

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