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Slc2a1 solute carrier family 2 member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24778, updated on 4-Jan-2025

Summary

Official Symbol
Slc2a1provided by RGD
Official Full Name
solute carrier family 2 member 1provided by RGD
Primary source
RGD:3704
See related
EnsemblRapid:ENSRNOG00000007284 AllianceGenome:RGD:3704
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GTG1; Gtg3; GLUTB; Glut1; RATGTG1
Summary
Enables several functions, including D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including D-glucose import; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 185.1), Kidney (RPKM 121.2) and 9 other tissues See more
Orthologs
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Genomic context

See Slc2a1 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (138002522..138030742)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (132717196..132745416)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (138154677..138182897)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 pseudogene Neighboring gene uncharacterized LOC108351021 Neighboring gene uncharacterized LOC120102964 Neighboring gene zinc finger protein 691 Neighboring gene erythroblast membrane associated protein (Scianna blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 27
Process Evidence Code Pubs
involved_in D-glucose import  
involved_in D-glucose import PubMed 
involved_in D-glucose import across plasma membrane  
involved_in D-glucose transmembrane transport PubMed 
involved_in D-glucose transmembrane transport  
involved_in D-glucose transmembrane transport  
involved_in cellular hyperosmotic response PubMed 
acts_upstream_of_or_within cellular response to glucose starvation  
involved_in cellular response to mechanical stimulus PubMed 
acts_upstream_of_or_within central nervous system development  
involved_in cerebral cortex development PubMed 
involved_in dehydroascorbic acid transport  
involved_in dehydroascorbic acid transport PubMed 
involved_in dehydroascorbic acid transport  
involved_in female pregnancy PubMed 
involved_in long-chain fatty acid import across plasma membrane  
involved_in photoreceptor cell maintenance  
involved_in photoreceptor cell maintenance  
involved_in protein-containing complex assembly  
involved_in protein-containing complex assembly  
involved_in response to Thyroglobulin triiodothyronine PubMed 
involved_in response to hypoxia PubMed 
involved_in response to insulin  
involved_in response to insulin PubMed 
acts_upstream_of_or_within transport across blood-brain barrier  
involved_in transport across blood-brain barrier  
involved_in xenobiotic transport PubMed 
Items 1 - 25 of 27
Items 1 - 20 of 34
Component Evidence Code Pubs
is_active_in Golgi membrane  
located_in Z disc PubMed 
is_active_in apical plasma membrane  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
is_active_in basolateral plasma membrane  
located_in basolateral plasma membrane PubMed 
located_in basolateral plasma membrane  
located_in caveola PubMed 
located_in cell-cell junction PubMed 
located_in cortical actin cytoskeleton  
located_in cortical actin cytoskeleton  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytosol  
located_in female germ cell nucleus  
located_in female pronucleus  
part_of glucose transporter complex  
located_in intercalated disc PubMed 
located_in membrane  
located_in membrane raft  
located_in midbody  
located_in photoreceptor inner segment  
located_in photoreceptor inner segment  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in presynapse  
located_in sarcolemma PubMed 
located_in synapse  
located_in vesicle  
Items 1 - 20 of 34

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 1
Names
GLUT-1
Solute carrier family 2 a 1 (facilitated glucose transporter) brain
glucose transporter type 1, erythrocyte/brain
solute carrier family 2 (facilitated glucose transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138827.2NP_620182.1  solute carrier family 2, facilitated glucose transporter member 1

    See identical proteins and their annotated locations for NP_620182.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P11167
    UniProtKB/TrEMBL
    A0A8I6ABD3, A6JZL0
    Related
    ENSRNOP00000061340.1, ENSRNOT00000064452.4
    Conserved Domains (1) summary
    cd17431
    Location:14458
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    138002522..138030742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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