Spn sialophorin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spnprovided by RGD
Official Full Name: sialophorinprovided by RGD
Primary source: RGD:3750
See related: Ensembl:ENSRNOG00000036711 AllianceGenome:RGD:3750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lsn; Cd43; Lsn1; gpL115
Summary: Enables protein domain specific binding activity. Involved in several processes, including T cell receptor signaling pathway; monocyte activation; and thymocyte aggregation. Located in cell surface; cleavage furrow; and microvillus. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 245.9), Spleen (RPKM 143.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191177449..191190115, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181746937..181759564, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198572999..198585664, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that a de-glycosylated form of CD43 in uterine epithelial cells moves from basally to apically at the time of blastocyst implantation, thus facilitating blastocyst attachment to uterine epithelial cells as well as their removal.
Title: CD43 is relocated from the basal to the apical plasma membrane of rat uterine epithelial cells by progesterone.
Of the 96 markers screened, we identified a marker, leukosianin, that shows polymorphism between the strains tested and thus appears to be quite useful for rat strain identification.
Title: DNA fingerprinting and phylogenetic analysis of WNIN rat strain and its obese mutants using microsatellite markers.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell costimulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T-helper 1 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in T-helper 1 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chronic inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocyte activation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type IV hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell activation	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in thymocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in uropod	ISO Inferred from Sequence Orthology more info
located_in uropod	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leukosialin

Names: W3/13 antigen; leukocyte sialoglycoprotein; leukosianin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.