Tbxa2r thromboxane A2 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbxa2rprovided by RGD
Official Full Name: thromboxane A2 receptorprovided by RGD
Primary source: RGD:3825
See related: Ensembl:ENSRNOG00000020585 AllianceGenome:RGD:3825
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables thromboxane receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of vasoconstriction; and response to testosterone. Located in acrosomal vesicle and plasma membrane. Used to study adult respiratory distress syndrome; kidney failure; thrombocytopenia; and toxic shock syndrome. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease; asthma; and blood platelet disease. Orthologous to human TBXA2R (thromboxane A2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 104.9), Lung (RPKM 32.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9034077..9041489, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8383347..8390753, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11253153..11259233, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thromboxane A2 receptors mediate chronic mechanoreflex sensitization in a rat model of simulated peripheral artery disease.
Title: Thromboxane A(2) receptors mediate chronic mechanoreflex sensitization in a rat model of simulated peripheral artery disease.
We conclude that hyperglycemia activates thromboxane A2 receptor to impair the integrity and function of blood-brain barrier via the ROCK-PTEN-Akt-eNOS pathway.
Title: Hyperglycemia via activation of thromboxane A2 receptor impairs the integrity and function of blood-brain barrier in microvascular endothelial cells.
the long-lasting oligemia following cortical spreading depression consists of at least two distinct temporal phases, mediated by preferential actions of COX-1- and COX-2-derived prostanoids: an initial phase mediated by COX-1 that involves TXA2 followed by a later phase, mediated by COX-2 and PGF2alpha.
Title: Differential contribution of COX-1 and COX-2 derived prostanoids to cortical spreading depression-Evoked cerebral oligemia.
Data suggest that thromboxane A2/Tbxa2r-mediated vasoconstriction of intracavernous small penile arteries depends on Ca2+ influx through L-type calcium channels and TRP (transient receptor potential) channels, and ROCK- (Rho kinase)-dependent mechanisms in vascular smooth muscle.
Title: Mechanisms Involved in Thromboxane A(2) -induced Vasoconstriction of Rat Intracavernous Small Penile Arteries.
The experiments suggest that in the SHR but not the WKY aorta, alpha1 -adrenoceptor activation desensitizes TP receptors through activation of PKC-epsilon.
Title: α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.
Low-dose TP stimulation constricts the ductus arteriosus with minimal adverse effects at least in rat neonates.
Title: Low-dose thromboxane A2 receptor stimulation promotes closure of the rat ductus arteriosus with minimal adverse effects.
analysis of hypersensitivity to the thromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute NO-deficiency in rats
Title: Hypersensitivity to thromboxane receptor mediated cerebral vasomotion and CBF oscillations during acute NO-deficiency in rats.
vasoconstrictor TP receptor and MaxiK-channel direct interaction facilitates G-protein-independent TP to MaxiK trans-inhibition, which would promote vasoconstriction.
Title: Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation.
Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.
Title: Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats.
Transcriptional down-regulation of thromboxane A(2) receptor expression via activation of MAPK ERK1/2, p38/NF-kappaB pathways.
Title: Transcriptional down-regulation of thromboxane A(2) receptor expression via activation of MAPK ERK1/2, p38/NF-kappaB pathways.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

BE111403 (e-PCR)
- UniSTS:245673

BI277919 (e-PCR)
- UniSTS:243912

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thromboxane receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables thromboxane receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thromboxane A2 receptor

Names: TXA2-R; TXR2; Thromboxane receptor; prostanoid TP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017054.2 → NP_058750.2 thromboxane A2 receptor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P34978

UniProtKB/TrEMBL

A6K895

Related

ENSRNOP00000027932.2, ENSRNOT00000027932.5

Conserved Domains (2) summary

cd14964
Location:26 → 52

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:25 → 317

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9034077..9041489 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263000.1 → XP_063119070.1 thromboxane A2 receptor isoform X1

UniProtKB/Swiss-Prot

P34978

UniProtKB/TrEMBL

A6K895
XM_006240846.4 → XP_006240908.1 thromboxane A2 receptor isoform X1

See identical proteins and their annotated locations for XP_006240908.1

UniProtKB/Swiss-Prot

P34978

UniProtKB/TrEMBL

A6K895

Conserved Domains (2) summary

cd14964
Location:26 → 52

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:25 → 317

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063262999.1 → XP_063119069.1 thromboxane A2 receptor isoform X1

UniProtKB/Swiss-Prot

P34978

UniProtKB/TrEMBL

A6K895