Clu clusterin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24854, updated on 13-Apr-2024

Summary

Official Symbol: Cluprovided by RGD
Official Full Name: clusterinprovided by RGD
Primary source: RGD:3907
See related: Ensembl:ENSRNOG00000016460 AllianceGenome:RGD:3907
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CLI; DAG; APOJ; SGP2; SP40; SGP-2; SP-40; Trpm2; Trpmb; TRPM-2; TRPM2B; RATTRPM2B
Summary: The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]
Expression: Biased expression in Heart (RPKM 3647.0), Liver (RPKM 1803.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (44336619..44375861)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (40161068..40200315)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (42626612..42665858)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells.
Title: Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells.
Perinatal undernourishment provokes long-lasting alterations of clusterin and fumarate hydratase expression in the rat nucleus accumbens.
Title: Perinatal undernourishment provokes long-lasting alterations of clusterin and fumarate hydratase expression in the rat nucleus accumbens.
Clusterin enhances cell survival by suppressing neuronal nitric-oxide synthase expression in the rhodopsin S334ter-line3 retinitis pigmentosa model.
Title: Clusterin enhances cell survival by suppressing neuronal nitric-oxide synthase expression in the rhodopsin S334ter-line3 retinitis pigmentosa model.
Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis.
Title: Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis.
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury.
Title: Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury.
increased CLU expression and secretion after myocardial infarction is, in part, due to a defect of ubiquitin proteasome system and macroautophagy activities in the heart.
Title: Increased clusterin levels after myocardial infarction is due to a defect in protein degradation systems activity.
ApoJ confers cytoprotection to Neonatal rat ventricular cells against Oxidized low-density lipoprotein cytotoxicity through the reactive oxygen species-CaMKII pathways.
Title: Apolipoprotein-J blocks increased cell injury elicited by ox-LDL via inhibiting ROS-CaMKII pathway.
clusterin might be involved in the formation of tubular complexes and parenchymal regeneration during rat pancreatitis
Title: Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats.
Results showed long-term alteration in protein levels of cPLA2 and clusterin, as well as their downstream autophagy markers Beclin-1, LC3, p62 and Cathepsin-E that is in parallel with cognitive deficits and hippocampal mossy fiber sprouting following recurrent prolonged neonatal seizures, which were restored by chronic ketogenic diet treatment
Title: Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures.
Results suggest that an increase in the secretion of clusterin by Sertoli cells protects the testes from heat stress-induced injury.
Title: Clusterin produced by Sertoli cells inhibits heat stress-induced apoptosis in the rat testis.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE111829 (e-PCR)
- UniSTS:245792

D15Wox2 (e-PCR)
- UniSTS:118054

RH94609 (e-PCR)
- UniSTS:119857

D15Wox8 (e-PCR)
- UniSTS:239434

D15Rat144 (e-PCR), detects polymorphism
- UniSTS:226704

D15Rat147 (e-PCR), detects polymorphism
- UniSTS:226707

Clu (e-PCR), detects polymorphism
- UniSTS:525479

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
NOT enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables misfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables misfolded protein binding	IEA Inferred from Electronic Annotation more info
enables misfolded protein binding	ISO Inferred from Sequence Orthology more info
enables misfolded protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein carrier chaperone	IEA Inferred from Electronic Annotation more info
enables protein carrier chaperone	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system myelin maintenance	IEA Inferred from Electronic Annotation more info
involved_in central nervous system myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelin maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in chaperone-mediated protein complex assembly	IEA Inferred from Electronic Annotation more info
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in chaperone-mediated protein folding	IEA Inferred from Electronic Annotation more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune complex clearance	IEA Inferred from Electronic Annotation more info
involved_in immune complex clearance	ISO Inferred from Sequence Orthology more info
involved_in immune complex clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microglial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in microglial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid fibril formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neurofibrillary tangle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurofibrillary tangle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurofibrillary tangle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import	IEA Inferred from Electronic Annotation more info
involved_in protein import	ISO Inferred from Sequence Orthology more info
involved_in protein import	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuronal signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to misfolded protein	IEA Inferred from Electronic Annotation more info
involved_in response to misfolded protein	ISO Inferred from Sequence Orthology more info
involved_in response to misfolded protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in aggresome	IDA Inferred from Direct Assay more info	PubMed
located_in apical dendrite	IEA Inferred from Electronic Annotation more info
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in chromaffin granule	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in neurofibrillary tangle	IEA Inferred from Electronic Annotation more info
located_in neurofibrillary tangle	ISO Inferred from Sequence Orthology more info
located_in neurofibrillary tangle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum lumen	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: clusterin

Names: dimeric acid glycoprotein; sulfated glycoprotein 2; testosterone repressed prostate message 2; testosterone-repressed prostate message; testostrone-repressed prostate message 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.