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Esr1 estrogen receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24890, updated on 7-Jan-2025

Summary

Official Symbol
Esr1provided by RGD
Official Full Name
estrogen receptor 1provided by RGD
Primary source
RGD:2581
See related
EnsemblRapid:ENSRNOG00000019358 AllianceGenome:RGD:2581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Esr; ER-alpha; RNESTROR
Summary
Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of signal transduction; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Uterus (RPKM 235.5), Kidney (RPKM 77.3) and 7 other tissues See more
Orthologs
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Genomic context

See Esr1 in Genome Data Viewer
Location:
1q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43511685..43904454)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (41106335..41499104)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (41192029..41594799)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482620 Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC134482628 Neighboring gene small nucleolar RNA SNORD88 Neighboring gene uncharacterized LOC134482627 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene uncharacterized LOC134482626

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 54
Function Evidence Code Pubs
enables 14-3-3 protein binding  
enables 14-3-3 protein binding  
enables ATPase binding  
enables ATPase binding  
enables DNA binding PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables G protein-coupled estrogen receptor activity  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables TBP-class protein binding  
enables TBP-class protein binding  
enables TFIIB-class transcription factor binding  
enables TFIIB-class transcription factor binding  
enables beta-catenin binding  
enables beta-catenin binding  
enables calmodulin binding  
enables chromatin binding  
enables chromatin binding  
enables chromatin binding  
enables enzyme binding PubMed 
enables enzyme binding  
enables estrogen response element binding  
enables estrogen response element binding  
enables estrogen response element binding  
enables hormone binding PubMed 
enables hormone binding PubMed 
enables identical protein binding  
enables identical protein binding  
enables nuclear estrogen receptor activity  
enables nuclear estrogen receptor activity  
enables nuclear estrogen receptor binding  
enables nuclear estrogen receptor binding  
enables nuclear receptor activity  
enables nuclear receptor activity  
enables nuclear steroid receptor activity PubMed 
enables phosphatidylinositol 3-kinase regulatory subunit binding PubMed 
enables promoter-specific chromatin binding PubMed 
enables protein binding PubMed 
enables protein kinase binding  
enables protein kinase binding  
enables protein-containing complex binding PubMed 
enables sequence-specific DNA binding  
enables sequence-specific DNA binding  
enables sequence-specific double-stranded DNA binding  
enables steroid binding PubMed 
enables steroid binding  
enables transcription coactivator binding  
enables transcription coactivator binding PubMed 
enables transcription coactivator binding  
enables transcription coregulator binding  
enables transcription corepressor binding  
enables transcription corepressor binding  
enables type 1 metabotropic glutamate receptor binding PubMed 
enables zinc ion binding  
Items 1 - 25 of 54
Items 1 - 25 of 100
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly  
involved_in RNA polymerase II preinitiation complex assembly  
involved_in Sertoli cell development PubMed 
involved_in Sertoli cell proliferation PubMed 
involved_in androgen metabolic process  
acts_upstream_of_or_within androgen metabolic process  
involved_in antral ovarian follicle growth  
acts_upstream_of_or_within antral ovarian follicle growth  
involved_in baculum development PubMed 
involved_in cellular response to estradiol stimulus PubMed 
involved_in cellular response to estradiol stimulus  
involved_in cellular response to estradiol stimulus  
involved_in cellular response to estrogen stimulus  
involved_in cellular response to estrogen stimulus  
involved_in cellular response to estrogen stimulus PubMed 
acts_upstream_of_or_within cellular response to estrogen stimulus  
involved_in cellular response to wortmannin PubMed 
involved_in decidualization PubMed 
involved_in epithelial cell development  
acts_upstream_of_or_within epithelial cell development  
involved_in epithelial cell proliferation involved in mammary gland duct elongation  
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation  
involved_in estrogen receptor signaling pathway  
involved_in estrogen receptor signaling pathway  
involved_in estrogen receptor signaling pathway  
involved_in fibroblast proliferation  
acts_upstream_of fibroblast proliferation  
involved_in male gonad development  
involved_in male gonad development PubMed 
acts_upstream_of_or_within male gonad development  
involved_in mammary gland alveolus development  
acts_upstream_of_or_within mammary gland alveolus development  
involved_in mammary gland branching involved in pregnancy  
acts_upstream_of_or_within mammary gland branching involved in pregnancy  
involved_in negative regulation of D-glucose import PubMed 
involved_in negative regulation of DNA-binding transcription factor activity  
involved_in negative regulation of DNA-binding transcription factor activity  
involved_in negative regulation of canonical NF-kappaB signal transduction  
involved_in negative regulation of canonical NF-kappaB signal transduction  
involved_in negative regulation of canonical NF-kappaB signal transduction  
involved_in negative regulation of gene expression  
involved_in negative regulation of gene expression  
involved_in negative regulation of miRNA transcription  
involved_in negative regulation of miRNA transcription  
involved_in negative regulation of neuron apoptotic process PubMed 
involved_in negative regulation of smooth muscle cell apoptotic process PubMed 
involved_in negative regulation of smooth muscle cell proliferation PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of triglyceride metabolic process PubMed 
involved_in nuclear receptor-mediated steroid hormone signaling pathway PubMed 
involved_in osteoblast development PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
involved_in positive regulation of DNA-binding transcription factor activity  
involved_in positive regulation of DNA-binding transcription factor activity  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of cytosolic calcium ion concentration PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway PubMed 
involved_in positive regulation of epithelial cell proliferation PubMed 
involved_in positive regulation of fibroblast proliferation  
acts_upstream_of_or_within positive regulation of fibroblast proliferation  
involved_in positive regulation of nitric oxide biosynthetic process  
involved_in positive regulation of nitric oxide biosynthetic process  
involved_in positive regulation of nitric-oxide synthase activity  
involved_in positive regulation of nitric-oxide synthase activity  
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  
involved_in prostate epithelial cord elongation  
acts_upstream_of_or_within prostate epithelial cord elongation  
involved_in protein localization to chromatin  
involved_in protein localization to chromatin  
involved_in regulation of DNA-templated transcription  
acts_upstream_of_or_within regulation of DNA-templated transcription  
involved_in regulation of branching involved in prostate gland morphogenesis  
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis  
involved_in regulation of epithelial cell apoptotic process  
acts_upstream_of_or_within regulation of epithelial cell apoptotic process  
involved_in regulation of inflammatory response  
acts_upstream_of_or_within regulation of inflammatory response  
involved_in regulation of toll-like receptor signaling pathway  
acts_upstream_of_or_within regulation of toll-like receptor signaling pathway  
involved_in regulation of transcription by RNA polymerase II  
involved_in response to estradiol PubMed 
involved_in response to estradiol  
involved_in response to estrogen  
involved_in stem cell differentiation  
involved_in stem cell differentiation  
involved_in steroid hormone receptor signaling pathway  
involved_in steroid hormone receptor signaling pathway  
acts_upstream_of transcription by RNA polymerase II  
involved_in uterus development  
acts_upstream_of_or_within uterus development  
involved_in vagina development  
acts_upstream_of_or_within vagina development  
Items 1 - 25 of 100
Items 1 - 20 of 22
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in T-tubule PubMed 
located_in chromatin  
located_in chromatin  
located_in cytoplasm  
located_in cytoplasm  
located_in euchromatin  
located_in euchromatin  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  
located_in nucleus  
located_in perikaryon PubMed 
located_in perinuclear region of cytoplasm PubMed 
located_in plasma membrane  
is_active_in plasma membrane  
located_in plasma membrane  
part_of protein-containing complex PubMed 
part_of protein-containing complex  
located_in terminal bouton PubMed 
part_of transcription regulator complex  
part_of transcription regulator complex  
Items 1 - 20 of 22

General protein information

Preferred Names
estrogen receptor
Names
C-terminally-truncated estrogen receptor alpha product-1
Er alpha
estradiol receptor
estrogen receptor 1 (alpha)
estrogen receptor alpha i45aL
estrogen receptor alpha i45aS
estrogen receptor alpha i45c
estrogen receptor alpha i56a
estrogen receptor alpha i56b
estrogen receptor alpha i56c
estrogen receptor alpha i56dL
estrogen receptor alpha i56dS
estrogen receptor alpha i56e
estrogen receptor alpha variant delta 4
estrogen receptor protein
nuclear receptor subfamily 3 group A member 1
trunctaed estrogen receptor product-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433730.1NP_001420659.1  estrogen receptor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P06211
    UniProtKB/TrEMBL
    A0A9K3Y766, D0FYH4, F1M839
  2. NM_001433731.1NP_001420660.1  estrogen receptor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P06211
    UniProtKB/TrEMBL
    A0A9K3Y766, D0FYH4, F1M839
  3. NM_012689.2NP_036821.2  estrogen receptor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P06211
    UniProtKB/TrEMBL
    A0A9K3Y766, D0FYH4, F1M839
    Related
    ENSRNOP00000071400.1, ENSRNOT00000078494.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    43511685..43904454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101049.2XP_038956977.1  estrogen receptor isoform X3

    UniProtKB/TrEMBL
    A0A1W7GYV1
    Conserved Domains (3) summary
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    cl11397
    Location:348454
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. XM_017588797.3XP_017444286.2  estrogen receptor isoform X6

    UniProtKB/TrEMBL
    A0A0G2K0D4
    Conserved Domains (4) summary
    cd06949
    Location:348617
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:626665
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  3. XM_039101051.2XP_038956979.1  estrogen receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I6AKJ6
    Conserved Domains (3) summary
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    cl11397
    Location:348450
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. XM_039101033.2XP_038956961.1  estrogen receptor isoform X1

    UniProtKB/Swiss-Prot
    P06211
    Conserved Domains (4) summary
    cd06949
    Location:348585
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:594633
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  5. XM_039101029.2XP_038956957.1  estrogen receptor isoform X1

    UniProtKB/Swiss-Prot
    P06211
    Conserved Domains (4) summary
    cd06949
    Location:348585
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:594633
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  6. XM_017588795.3XP_017444284.1  estrogen receptor isoform X2

    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:561600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  7. XM_006227832.5XP_006227894.1  estrogen receptor isoform X2

    See identical proteins and their annotated locations for XP_006227894.1

    UniProtKB/Swiss-Prot
    P06211
    UniProtKB/TrEMBL
    A0A9K3Y766, D0FYH4, F1M839
    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:561600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  8. XM_008758704.4XP_008756926.1  estrogen receptor isoform X2

    See identical proteins and their annotated locations for XP_008756926.1

    UniProtKB/Swiss-Prot
    P06211
    UniProtKB/TrEMBL
    A0A9K3Y766, D0FYH4, F1M839
    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:561600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  9. XM_063281065.1XP_063137135.1  estrogen receptor isoform X2

  10. XM_017588796.3XP_017444285.1  estrogen receptor isoform X5

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