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F9 coagulation factor IX [ Rattus norvegicus (Norway rat) ]

Gene ID: 24946, updated on 4-Jan-2025

Summary

Official Symbol
F9provided by RGD
Official Full Name
coagulation factor IXprovided by RGD
Primary source
RGD:2589
See related
EnsemblRapid:ENSRNOG00000003430 AllianceGenome:RGD:2589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation and zymogen activation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Orthologous to human F9 (coagulation factor IX). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 2185.3) See more
Orthologs
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Genomic context

Location:
Xq36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (143388642..143433143)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (138352334..138396835)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (143097507..143141791)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene synaptophysin-like 1, pseudogene 1 Neighboring gene zinc finger protein 431-like Neighboring gene MCF.2 cell line derived transforming sequence Neighboring gene ATPase phospholipid transporting 11C Neighboring gene microRNA 3589 Neighboring gene microRNA 505

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium ion binding  
enables calcium ion binding  
enables endopeptidase activity  
enables endopeptidase activity  
enables metal ion binding  
enables peptidase activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
Process Evidence Code Pubs
involved_in blood coagulation  
involved_in blood coagulation  
acts_upstream_of_or_within blood coagulation  
involved_in blood coagulation  
involved_in proteolysis  
involved_in proteolysis  
involved_in zymogen activation  
involved_in zymogen activation  
involved_in zymogen activation  
involved_in zymogen activation  
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
coagulation factor IX
Names
Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
christmas factor
coagulation factor 9
NP_113728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031540.1NP_113728.1  coagulation factor IX precursor

    See identical proteins and their annotated locations for NP_113728.1

    Status: VALIDATED

    Source sequence(s)
    FM036569, JAXUCZ010000021, M26247
    UniProtKB/Swiss-Prot
    F1M1M6, P16296
    UniProtKB/TrEMBL
    A0A8L2Q0X9
    Related
    ENSRNOP00000004559.7, ENSRNOT00000004559.9
    Conserved Domains (5) summary
    smart00020
    Location:227455
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:2185
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:86122
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:228458
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:127163
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    143388642..143433143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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