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Gcgr glucagon receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24953, updated on 4-Jan-2025

Summary

Official Symbol
Gcgrprovided by RGD
Official Full Name
glucagon receptorprovided by RGD
Primary source
RGD:2669
See related
EnsemblRapid:ENSRNOG00000036692 AllianceGenome:RGD:2669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables glucagon receptor activity and peptide hormone binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; exocytosis; and hormone-mediated signaling pathway. Located in endosome. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 206.9), Kidney (RPKM 67.8) and 5 other tissues See more
Orthologs
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Genomic context

See Gcgr in Genome Data Viewer
Location:
10q32.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106306803..106314970)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105808474..105816641)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109707863..109716253)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene solute carrier family 25 member 10 Neighboring gene uncharacterized LOC103693493 Neighboring gene MAPK regulated co-repressor interacting protein 1 Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 like 1 Neighboring gene protein phosphatase 1, regulatory subunit 27

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC93090

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glucagon receptor activity  
enables glucagon receptor activity PubMed 
enables glucagon receptor activity  
enables glucagon receptor activity PubMed 
enables glucagon receptor activity  
enables peptide hormone binding  
enables peptide hormone binding PubMed 
enables peptide hormone binding PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
involved_in cell surface receptor signaling pathway  
involved_in cellular response to glucagon stimulus  
involved_in cellular response to glucagon stimulus  
acts_upstream_of_or_within cellular response to starvation  
involved_in exocytosis PubMed 
involved_in glucose homeostasis  
involved_in glucose homeostasis  
involved_in hormone-mediated signaling pathway PubMed 
involved_in hormone-mediated signaling pathway PubMed 
acts_upstream_of_or_within positive regulation of gene expression  
involved_in regulation of glycogen metabolic process  
involved_in regulation of glycogen metabolic process  
involved_in response to starvation  
involved_in response to starvation  
Component Evidence Code Pubs
located_in endosome PubMed 
located_in membrane  
is_active_in plasma membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
glucagon receptor
Names
GL-R
glucagon receptor perhaps same as Niddm3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430043.1NP_001416972.1  glucagon receptor isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
  2. NM_001430044.1NP_001416973.1  glucagon receptor isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
  3. NM_001430045.1NP_001416974.1  glucagon receptor isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
  4. NM_172091.3NP_742088.1  glucagon receptor isoform a precursor

    See identical proteins and their annotated locations for NP_742088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal non-coding exon, therefore, has a different 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P30082
    UniProtKB/TrEMBL
    A6HLE4
    Conserved Domains (2) summary
    cd15267
    Location:137418
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:56123
    HRM; Hormone receptor domain
  5. NM_172092.3NP_742089.1  glucagon receptor isoform a precursor

    See identical proteins and their annotated locations for NP_742089.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P30082
    UniProtKB/TrEMBL
    A6HLE4
    Related
    ENSRNOP00000107799.1, ENSRNOT00000153208.1
    Conserved Domains (2) summary
    cd15267
    Location:137418
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:56123
    HRM; Hormone receptor domain

RNA

  1. NR_073147.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOT00000088898.3
  2. NR_190841.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106306803..106314970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768468.4XP_008766690.1  glucagon receptor isoform X1

    Conserved Domains (2) summary
    pfam00002
    Location:144380
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:61128
    HRM; Hormone receptor domain
  2. XM_008768469.4XP_008766691.1  glucagon receptor isoform X3

    Conserved Domains (2) summary
    pfam00002
    Location:144380
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:61128
    HRM; Hormone receptor domain
  3. XM_039085247.2XP_038941175.1  glucagon receptor isoform X6

    Conserved Domains (3) summary
    pfam02793
    Location:61128
    HRM; Hormone receptor domain
    cd14964
    Location:146171
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:142299
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_039085243.2XP_038941171.1  glucagon receptor isoform X2

    UniProtKB/Swiss-Prot
    P30082
    UniProtKB/TrEMBL
    A6HLE4
    Conserved Domains (2) summary
    cd15267
    Location:137418
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:56123
    HRM; Hormone receptor domain
  5. XM_006247877.3XP_006247939.1  glucagon receptor isoform X4

    Related
    ENSRNOP00000051845.2, ENSRNOT00000054962.4
    Conserved Domains (1) summary
    pfam00002
    Location:103339
    7tm_2; 7 transmembrane receptor (Secretin family)
  6. XM_039085245.2XP_038941173.1  glucagon receptor isoform X5

    UniProtKB/TrEMBL
    Q66HT0
    Conserved Domains (1) summary
    cd15267
    Location:26307
    7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
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