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Hk3 hexokinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25060, updated on 2-May-2024

Summary

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Official Symbol
Hk3provided by RGD
Official Full Name
hexokinase 3provided by RGD
Primary source
RGD:2798
See related
Ensembl:ENSRNOG00000026235 AllianceGenome:RGD:2798
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RNU73859
Summary
Enables enzyme binding activity; hexokinase activity; and hormone binding activity. Involved in fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; and negative regulation of hydrogen peroxide-mediated programmed cell death. Part of protein-containing complex. Orthologous to human HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 24.4), Spleen (RPKM 22.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17p14
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9602119..9620038)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9596950..9614847)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10134726..10152976)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 346 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene unc-5 netrin receptor A Neighboring gene uncharacterized LOC120097834 Neighboring gene tetraspanin 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spatio-temporal expression of Hexokinase-3 in the injured female rat spinal cords. Lin YH, et al. Neurochem Int, 2018 Feb. PMID 29196144
  2. Complete amino acid sequence of the type III isozyme of rat hexokinase, deduced from the cloned cDNA. Schwab DA, et al. Arch Biochem Biophys, 1991 Mar. PMID 1897938
  3. Regulation and cytoprotective role of hexokinase III. Wyatt E, et al. PLoS One, 2010 Nov 3. PMID 21072205, Free PMC Article
  4. Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. Palma F, et al. Mol Cell Biochem, 1996 Feb 9. PMID 8717435
  5. A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum- transplantation antigen P198. Chan YL, et al. J Biol Chem, 1994 Feb 25. PMID 8119894

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HK3 may be involved in the pathologic process ofspinal cord injury by promoting glucose metabolism.
    Title: Spatio-temporal expression of Hexokinase-3 in the injured female rat spinal cords.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose binding IEA
Inferred from Electronic Annotation
more info
  
enables hexokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hormone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in carbohydrate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hexokinase-3
Names
HK III
hexokinase 3 (white cell)
hexokinase type III
hexokinase-C
NP_071515.1
XP_006253665.1
XP_038951301.1
XP_063132145.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022179.2 → NP_071515.1  hexokinase-3

    See identical proteins and their annotated locations for NP_071515.1

    Status: PROVISIONAL

    Source sequence(s)
    U73859
    UniProtKB/Swiss-Prot
    P27926, Q497A1
    UniProtKB/TrEMBL
    A0A0G2JTY2
    Related
    ENSRNOP00000031587.1, ENSRNOT00000031935.3
    Conserved Domains (3) summary
    PTZ00107
    Location:23 → 474
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:482 → 674
    Hexokinase_1
    pfam03727
    Location:680 → 912
    Hexokinase_2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    9602119..9620038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253603.5 → XP_006253665.1  hexokinase-3 isoform X1

    See identical proteins and their annotated locations for XP_006253665.1

    UniProtKB/TrEMBL
    A0A0G2JST6, A0A0G2JTY2, A6KAV7
    Conserved Domains (3) summary
    PTZ00107
    Location:23 → 474
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:482 → 674
    Hexokinase_1
    pfam03727
    Location:680 → 914
    Hexokinase_2

  2. XM_063276075.1 → XP_063132145.1  hexokinase-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JST6, A6KAV7

  3. XM_039095373.2 → XP_038951301.1  hexokinase-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JST6, A0A0G2JTY2, A6KAV7
    Related
    ENSRNOP00000068888.1
    Conserved Domains (3) summary
    PTZ00107
    Location:23 → 474
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:482 → 674
    Hexokinase_1
    pfam03727
    Location:680 → 914
    Hexokinase_2

RNA

  1. XR_005495237.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27926.1 GenPept UniProtKB/Swiss-Prot:P27926

Gene LinkOut

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