Ampd3 adenosine monophosphate deaminase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ampd3provided by RGD
Official Full Name: adenosine monophosphate deaminase 3provided by RGD
Primary source: RGD:2111
See related: Ensembl:ENSRNOG00000018262 AllianceGenome:RGD:2111
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables AMP deaminase activity. Predicted to be involved in erythrocyte homeostasis and purine ribonucleotide metabolic process. Predicted to act upstream of or within ADP metabolic process; ATP metabolic process; and energy homeostasis. Predicted to be active in cytosol. Orthologous to human AMPD3 (adenosine monophosphate deaminase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 67.7), Spleen (RPKM 46.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (174319526..174364605)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (164884823..164929899)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (175585301..175630479)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca[2+] overload in type 2 diabetes rat hearts.
Title: Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca(2+) overload in type 2 diabetes rat hearts.
The results indicate that translational regulation by miR-301b mediates upregulated expression of cardiac AMPD3 protein in OLETF, which potentially reduces the adenine nucleotide pool at the time of increased work load. The miR-301b-AMPD3 axis may be a novel therapeutic target for intervening enegy metabolism in diabetic hearts.
Title: Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142177 (e-PCR)
- UniSTS:231427

RH139645 (e-PCR)
- UniSTS:221729

MARC_44785-45781:1101739916:1 (e-PCR)
- UniSTS:471626

MARC_45777-45778:1101741591:5 (e-PCR)
- UniSTS:471628

D1Bda34 (e-PCR)
- UniSTS:239781

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMP deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables AMP deaminase activity	IEA Inferred from Electronic Annotation more info
enables AMP deaminase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in AMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in AMP catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within AMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in AMP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within IMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in IMP salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AMP deaminase 3

Names: Ampd

NP_113732.2

EC 3.5.4.6

XP_006230072.1

EC 3.5.4.6

XP_006230073.1

EC 3.5.4.6

XP_006230074.1

EC 3.5.4.6

XP_006230075.1

EC 3.5.4.6

XP_006230076.1

EC 3.5.4.6

XP_006230077.1

EC 3.5.4.6

XP_038957285.1

EC 3.5.4.6

XP_038957300.1

EC 3.5.4.6

XP_063137312.1

EC 3.5.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031544.2 → NP_113732.2 AMP deaminase 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O09178

UniProtKB/TrEMBL

A6I819, F1M7Q5

Related

ENSRNOP00000024933.5, ENSRNOT00000024933.6

Conserved Domains (1) summary

TIGR01429
Location:181 → 787

AMP_deaminase; AMP deaminase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

174319526..174364605

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230014.5 → XP_006230076.1 AMP deaminase 3 isoform X3

See identical proteins and their annotated locations for XP_006230076.1

UniProtKB/Swiss-Prot

O09178

UniProtKB/TrEMBL

A6I821

Conserved Domains (1) summary

TIGR01429
Location:145 → 751

AMP_deaminase; AMP deaminase
XM_063281242.1 → XP_063137312.1 AMP deaminase 3 isoform X4
XM_006230011.4 → XP_006230073.1 AMP deaminase 3 isoform X2

UniProtKB/TrEMBL

A0A8I6A0N2, A6I820

Related

ENSRNOP00000084681.1

Conserved Domains (2) summary

PLN03055
Location:197 → 761

PLN03055; AMP deaminase; Provisional

TIGR01429
Location:154 → 760

AMP_deaminase; AMP deaminase
XM_006230015.5 → XP_006230077.1 AMP deaminase 3 isoform X3

See identical proteins and their annotated locations for XP_006230077.1

UniProtKB/Swiss-Prot

O09178

UniProtKB/TrEMBL

A6I821

Conserved Domains (1) summary

TIGR01429
Location:145 → 751

AMP_deaminase; AMP deaminase
XM_006230013.5 → XP_006230075.1 AMP deaminase 3 isoform X3

See identical proteins and their annotated locations for XP_006230075.1

UniProtKB/Swiss-Prot

O09178

UniProtKB/TrEMBL

A6I821

Conserved Domains (1) summary

TIGR01429
Location:145 → 751

AMP_deaminase; AMP deaminase
XM_006230012.5 → XP_006230074.1 AMP deaminase 3 isoform X3

See identical proteins and their annotated locations for XP_006230074.1

UniProtKB/Swiss-Prot

O09178

UniProtKB/TrEMBL

A6I821

Conserved Domains (1) summary

TIGR01429
Location:145 → 751

AMP_deaminase; AMP deaminase
XM_006230010.5 → XP_006230072.1 AMP deaminase 3 isoform X1

UniProtKB/TrEMBL

A0A8I6A9F8, A6I820

Related

ENSRNOP00000088165.1

Conserved Domains (2) summary

PLN03055
Location:212 → 776

PLN03055; AMP deaminase; Provisional

TIGR01429
Location:169 → 775

AMP_deaminase; AMP deaminase
XM_039101357.2 → XP_038957285.1 AMP deaminase 3 isoform X3

UniProtKB/Swiss-Prot

O09178

UniProtKB/TrEMBL

A6I821

Conserved Domains (1) summary

TIGR01429
Location:145 → 751

AMP_deaminase; AMP deaminase
XM_039101372.2 → XP_038957300.1 AMP deaminase 3 isoform X5

Conserved Domains (1) summary

cl00281
Location:1 → 430

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...