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Pcsk2 proprotein convertase subtilisin/kexin type 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25121, updated on 4-Jan-2025

Summary

Official Symbol
Pcsk2provided by RGD
Official Full Name
proprotein convertase subtilisin/kexin type 2provided by RGD
Primary source
RGD:3273
See related
EnsemblRapid:ENSRNOG00000005438 AllianceGenome:RGD:3273
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables serine-type endopeptidase activity. Involved in islet amyloid polypeptide processing. Located in dendrite; perikaryon; and secretory granule. Used to study chronic kidney disease. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 369.2) See more
Orthologs
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Genomic context

See Pcsk2 in Genome Data Viewer
Location:
3q41
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (151333938..151636628)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (130880422..131183127)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (137618891..137923385)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101719 Neighboring gene otoraplin Neighboring gene WW domain binding protein 4, pseudogene 1 Neighboring gene uncharacterized LOC134486455 Neighboring gene beaded filament structural protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity  
enables protein binding PubMed 
enables serine-type endopeptidase activity PubMed 
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity PubMed 
enables serine-type endopeptidase activity  
Process Evidence Code Pubs
involved_in enkephalin processing  
involved_in insulin processing  
involved_in islet amyloid polypeptide processing PubMed 
involved_in nervous system development  
involved_in peptide hormone processing  
involved_in peptide hormone processing PubMed 
acts_upstream_of_or_within peptide hormone processing  
involved_in peptide hormone processing  
involved_in peptide hormone processing  
involved_in protein autoprocessing  
involved_in protein processing PubMed 
involved_in protein processing  
involved_in proteolysis  
acts_upstream_of_or_within proteolysis  
involved_in proteolysis  
Component Evidence Code Pubs
located_in dendrite PubMed 
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in intracellular membrane-bounded organelle  
is_active_in membrane  
located_in membrane  
is_active_in neuron projection  
located_in neuronal cell body PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
located_in perikaryon PubMed 
located_in secretory granule PubMed 
is_active_in secretory granule  
located_in secretory granule lumen  
located_in transport vesicle  

General protein information

Preferred Names
neuroendocrine convertase 2
Names
KEX2-like endoprotease 2
NEC 2
PC2
prohormone convertase 2
proprotein convertase 2
NP_036878.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012746.2NP_036878.1  neuroendocrine convertase 2 precursor

    See identical proteins and their annotated locations for NP_036878.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P28841
    UniProtKB/TrEMBL
    A0A8I6A2I9, A6K734
    Related
    ENSRNOP00000007249.3, ENSRNOT00000007249.6
    Conserved Domains (4) summary
    cd04059
    Location:121417
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:157434
    Peptidase_S8; Subtilase family
    pfam01483
    Location:503590
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:32108
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    151333938..151636628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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