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Slc2a4 solute carrier family 2 member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25139, updated on 4-Jan-2025

Summary

Official Symbol
Slc2a4provided by RGD
Official Full Name
solute carrier family 2 member 4provided by RGD
Primary source
RGD:2711
See related
EnsemblRapid:ENSRNOG00000017226 AllianceGenome:RGD:2711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Glut4
Summary
Enables D-glucose uniporter activity. Involved in several processes, including cellular response to hypoxia; glucose import in response to insulin stimulus; and regulation of synaptic vesicle budding from presynaptic endocytic zone membrane. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 955.0), Heart (RPKM 746.4) and 4 other tissues See more
Orthologs
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Genomic context

See Slc2a4 in Genome Data Viewer
Location:
10q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55164721..55170289, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54666015..54671581, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56552921..56558562, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box binding protein 2 Neighboring gene cofilin-1-like Neighboring gene claudin 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC93607

Gene Ontology Provided by RGD

Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in D-glucose import  
involved_in D-glucose import PubMed 
involved_in D-glucose transmembrane transport PubMed 
involved_in D-glucose transmembrane transport  
involved_in D-glucose transmembrane transport PubMed 
acts_upstream_of_or_within D-glucose transmembrane transport  
acts_upstream_of_or_within amylopectin biosynthetic process  
acts_upstream_of_or_within brown fat cell differentiation  
involved_in cellular response to hypoxia PubMed 
involved_in cellular response to insulin stimulus  
involved_in cellular response to insulin stimulus  
involved_in cellular response to insulin stimulus PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus  
involved_in cellular response to insulin stimulus  
acts_upstream_of_or_within cellular response to osmotic stress  
acts_upstream_of_or_within cellular response to tumor necrosis factor  
involved_in dehydroascorbic acid transport  
acts_upstream_of_or_within glucose homeostasis  
involved_in glucose homeostasis  
involved_in glucose import in response to insulin stimulus PubMed 
acts_upstream_of_or_within glucose import in response to insulin stimulus  
involved_in glucose import in response to insulin stimulus  
involved_in glucose import in response to insulin stimulus  
acts_upstream_of_or_within learning or memory PubMed 
acts_upstream_of_or_within_positive_effect long-term memory PubMed 
acts_upstream_of_or_within positive regulation of brain-derived neurotrophic factor receptor signaling pathway PubMed 
involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane PubMed 
involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane PubMed 
involved_in response to ethanol PubMed 
acts_upstream_of_or_within_negative_effect short-term memory PubMed 
Items 1 - 25 of 30
Items 1 - 20 of 38
Component Evidence Code Pubs
located_in T-tubule PubMed 
located_in cell surface PubMed 
located_in clathrin-coated pit PubMed 
located_in clathrin-coated vesicle  
located_in cytoplasm PubMed 
located_in cytoplasmic vesicle membrane  
located_in cytoplasmic vesicle membrane  
located_in cytosol  
is_active_in endomembrane system  
located_in endomembrane system  
located_in endomembrane system  
located_in endosome PubMed 
located_in endosome  
located_in external side of plasma membrane  
located_in extracellular exosome  
located_in insulin-responsive compartment PubMed 
located_in insulin-responsive compartment  
located_in membrane  
located_in membrane raft  
located_in multivesicular body PubMed 
is_active_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm PubMed 
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
is_active_in plasma membrane  
located_in plasma membrane  
is_active_in presynapse PubMed 
is_active_in presynapse PubMed 
located_in sarcolemma PubMed 
located_in sarcolemma  
located_in sarcoplasmic reticulum PubMed 
located_in trans-Golgi network  
located_in trans-Golgi network transport vesicle  
located_in vesicle PubMed 
located_in vesicle membrane  
Items 1 - 20 of 38

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 4
Names
GLUT-4
Glucose transporter 4, insuline-responsive
glucose transporter 4 insulin-responsive
glucose transporter type 4, insulin-responsive
insulin responsive glucose transporter
solute carrier family 2 (facilitated glucose transporter), member 4
solute carrier family 2 , member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430054.1NP_001416983.1  solute carrier family 2, facilitated glucose transporter member 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P19357, P97900
    UniProtKB/TrEMBL
    A0A8I6B1R2, A6HFY2
  2. NM_001430055.1NP_001416984.1  solute carrier family 2, facilitated glucose transporter member 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AM71
  3. NM_012751.2NP_036883.1  solute carrier family 2, facilitated glucose transporter member 4 isoform a

    See identical proteins and their annotated locations for NP_036883.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P19357, P97900
    UniProtKB/TrEMBL
    A0A8I6B1R2, A6HFY2
    Related
    ENSRNOP00000023256.3, ENSRNOT00000023256.7
    Conserved Domains (2) summary
    cd06174
    Location:78447
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:27483
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55164721..55170289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246596.5XP_006246658.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:78447
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:27483
    Sugar_tr; Sugar (and other) transporter
  2. XM_063268455.1XP_063124525.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AM71
    Related
    ENSRNOP00000090027.1, ENSRNOT00000095666.2
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