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St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25197, updated on 2-May-2024

Summary

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Official Symbol
St6gal1provided by RGD
Official Full Name
ST6 beta-galactoside alpha-2,6-sialyltransferase 1provided by RGD
Primary source
RGD:3676
See related
Ensembl:ENSRNOG00000001823 AllianceGenome:RGD:3676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat1
Summary
Enables sialyltransferase activity. Involved in several processes, including negative regulation of macrophage apoptotic process; protein sialylation; and regulation of substrate adhesion-dependent cell spreading. Located in Golgi medial cisterna; Golgi trans cisterna; and endoplasmic reticulum. Used to study high grade glioma. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1020.2), Kidney (RPKM 382.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St6gal1 in Genome Data Viewer
Location:
11q23
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91031481..91158111, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77526837..77653474, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (80927601..80981424, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microtubule associated serine/threonine kinase 2, pseudogene 1 Neighboring gene uncharacterized LOC120095690 Neighboring gene ST6 beta-galactoside alpha-2,6-sialyltransferase 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. Meng L, et al. J Biol Chem, 2013 Nov 29. PMID 24155237, Free PMC Article
  2. Development of sandwich enzyme-linked immunosorbent assay systems for plasma beta-galactoside alpha2,6-sialyltransferase, a possible hepatic disease biomarker. Futakawa S, et al. Anal Chim Acta, 2009 Jan 5. PMID 19046688
  3. The two rat alpha 2,6-sialyltransferase (ST6Gal I) isoforms: evaluation of catalytic activity and intra-Golgi localization. Chen TL, et al. Glycobiology, 2003 Feb. PMID 12626411
  4. Alpha2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo. Yamamoto H, et al. Cancer Res, 2001 Sep 15. PMID 11559557
  5. Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells. Seo NS, et al. Protein Expr Purif, 2001 Jul. PMID 11437599

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparisons of the structure with pig ST3GAL1 and a bacterial sialyltransferase revealed a similar positioning of donor, acceptor, and catalytic residues that provide a common structural framework for catalysis
    Title: Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation.
  2. ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor.
    Title: ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptor.
  3. rat ST6GAL1 mRNA possess an L exon, suggesting conservation of this regulatory element in rodents
    Title: Conservation of the ST6Gal I gene and its expression in the mammary gland.
  4. There are two possible mechanisms for the upregulation of plasma ST6Gal I in hepatopathological situations: one accompanied by acute phase reactions to increase hepatic ST6Gal I expression and the other triggered by oxidative stress in the liver.
    Title: Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo.
  5. soluble ST6Gal I produced by BACE1 plays, at least in part, a role in the sialylation of soluble glycoproteins
    Title: Beta-galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation.
  6. Results suggest that ST6Gal I is cleaved initially between Leu(37) and Gln(38) by BACE1, and then the three-amino acid sequence at the NH(2) terminus is removed by exopeptidase(s) before secretion from the cells.
    Title: Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).
  7. BACE1 cleaves ST6Gal I in vivo and controls the secretion of the E41 form of the ST6Gal I protein
    Title: In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.
  8. The addition of rat alpha 2,6-sialyltransferase in a metabolically engineered baculovirus-infected insect cell system enables successful production of sialylated glycoprotein.
    Title: Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acetylneuraminate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylneuraminate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of macrophage apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mononuclear cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation via asparagine ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sialylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi medial cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 1
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6Gal I
ST6GalI
Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)
Sialyltransferase 1 (beta-galactoside alpha-26-sialytransferase)
alpha 2,6-ST 1
NP_001106815.1
NP_671738.2
XP_006248563.1
XP_038943921.1
XP_038943922.1
XP_038943923.1
XP_038943924.1
XP_038943925.1
XP_063126365.1
XP_063126366.1
XP_063126367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113344.1 → NP_001106815.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001106815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000011, M18769
    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_147205.2 → NP_671738.2  beta-galactoside alpha-2,6-sialyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_671738.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    BF418553, JAXUCZ010000011, M83143
    UniProtKB/TrEMBL
    F2Z3S3
    Related
    ENSRNOP00000041089.3, ENSRNOT00000044591.7
    Conserved Domains (1) summary
    pfam00777
    Location:63 → 190
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    91031481..91158111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087995.2 → XP_038943923.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_063270296.1 → XP_063126366.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721

  3. XM_039087993.2 → XP_038943921.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_006248501.3 → XP_006248563.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006248563.1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Related
    ENSRNOP00000002496.6
    Conserved Domains (1) summary
    pfam00777
    Location:166 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_039087996.2 → XP_038943924.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. XM_039087994.2 → XP_038943922.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_063270295.1 → XP_063126365.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721

  8. XM_063270297.1 → XP_063126367.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721

  9. XM_039087997.2 → XP_038943925.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    D4ABR2, G3V680, P13721
    Conserved Domains (1) summary
    pfam00777
    Location:166 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13721.2 GenPept UniProtKB/Swiss-Prot:P13721

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