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Pcsk1 proprotein convertase subtilisin/kexin type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25204, updated on 4-Jan-2025

Summary

Official Symbol
Pcsk1provided by RGD
Official Full Name
proprotein convertase subtilisin/kexin type 1provided by RGD
Primary source
RGD:3272
See related
EnsemblRapid:ENSRNOG00000011107 AllianceGenome:RGD:3272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BDP; PC1; PC3
Summary
Enables endopeptidase activity. Involved in several processes, including nervous system development; protein processing; and response to interleukin-1. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and trans-Golgi network. Used to study hyperglycemia and type 2 diabetes mellitus. Biomarker of glucose metabolism disease (multiple); hyperthyroidism; hypothyroidism; islet cell tumor; and visual epilepsy. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 49.8), Spleen (RPKM 29.7) and 8 other tissues See more
Orthologs
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Genomic context

See Pcsk1 in Genome Data Viewer
Location:
2q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (6130045..6176974)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (4395543..4442434)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (91450162..91497091, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485561 Neighboring gene calpastatin Neighboring gene RNA, U6 small nuclear 1303 Neighboring gene ribosomal protein L17, pseudogene 1 Neighboring gene uncharacterized LOC134485562

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity PubMed 
enables endopeptidase activity PubMed 
enables endopeptidase activity  
enables identical protein binding  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
Items 1 - 25 of 26
Process Evidence Code Pubs
involved_in insulin processing  
involved_in neurogenesis PubMed 
involved_in pancreas development PubMed 
involved_in peptide biosynthetic process  
involved_in peptide hormone processing  
involved_in peptide hormone processing PubMed 
involved_in peptide hormone processing PubMed 
involved_in peptide hormone processing  
involved_in pituitary gland development PubMed 
involved_in positive regulation of protein secretion PubMed 
involved_in positive regulation of protein secretion PubMed 
involved_in protein autoprocessing PubMed 
involved_in protein processing PubMed 
involved_in protein processing  
involved_in response to axon injury PubMed 
involved_in response to calcium ion PubMed 
involved_in response to chlorate PubMed 
involved_in response to fatty acid PubMed 
involved_in response to glucocorticoid PubMed 
involved_in response to glucose PubMed 
involved_in response to interleukin-1 PubMed 
involved_in response to lipopolysaccharide PubMed 
involved_in response to nutrient levels PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to peptide hormone PubMed 
involved_in response to xenobiotic stimulus PubMed 
Items 1 - 25 of 26
Component Evidence Code Pubs
located_in axon terminus PubMed 
located_in dendrite PubMed 
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
is_active_in membrane  
is_active_in neuron projection  
located_in neuronal cell body PubMed 
located_in perikaryon PubMed 
located_in perinuclear region of cytoplasm PubMed 
located_in secretory granule PubMed 
is_active_in secretory granule  
located_in secretory granule lumen  
located_in trans-Golgi network PubMed 
located_in transport vesicle  

General protein information

Preferred Names
neuroendocrine convertase 1
Names
NEC 1
Protein convertase subtilisin / kexin, type I
prohormone convertase 1
prohormone convertase 3
proprotein convertase 1
NP_058787.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017091.2 → NP_058787.1  neuroendocrine convertase 1 precursor

    See identical proteins and their annotated locations for NP_058787.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002, M76705, M83745
    UniProtKB/Swiss-Prot
    P28840
    UniProtKB/TrEMBL
    A6I4E7
    Related
    ENSRNOP00000015185.2, ENSRNOT00000015185.5
    Conserved Domains (4) summary
    cd04059
    Location:121 → 415
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:504 → 591
    P_proprotein; Proprotein convertase P-domain
    pfam12177
    Location:712 → 750
    Proho_convert; Prohormone convertase enzyme
    pfam16470
    Location:34 → 110
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    6130045..6176974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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