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Chrna7 cholinergic receptor nicotinic alpha 7 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 25302, updated on 4-Jan-2025

Summary

Official Symbol
Chrna7provided by RGD
Official Full Name
cholinergic receptor nicotinic alpha 7 subunitprovided by RGD
Primary source
RGD:2348
See related
EnsemblRapid:ENSRNOG00000010853 AllianceGenome:RGD:2348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BTX; NARAD; nAChRa7
Summary
Enables several functions, including acetylcholine binding activity; acetylcholine-gated monoatomic cation-selective channel activity; and enzyme binding activity. Involved in several processes, including neuronal action potential; regulation of ERK1 and ERK2 cascade; and synaptic signaling. Acts upstream of or within calcium ion transport and regulation of membrane potential. Located in several cellular components, including dendrite; growth cone; and plasma membrane raft. Part of acetylcholine-gated channel complex. Is active in several cellular components, including glycinergic synapse; spine apparatus membrane; and synaptic membrane. Used to study cognitive disorder. Biomarker of rheumatoid arthritis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 33.6), Brain (RPKM 22.8) and 2 other tissues See more
Orthologs
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Genomic context

See Chrna7 in Genome Data Viewer
Location:
1q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (126123425..126249181, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (116711559..116837269, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (123897341..124039263, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene non-POU domain-containing octamer-binding protein-like Neighboring gene POTE ankyrin domain family member 2 Neighboring gene F-box and WD repeat domain containing 11, pseudogene 1 Neighboring gene uncharacterized LOC102548165 Neighboring gene uncharacterized LOC102548323

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding PubMed 
enables acetylcholine binding PubMed 
enables acetylcholine binding PubMed 
enables acetylcholine binding  
enables acetylcholine receptor activity  
enables acetylcholine-gated monoatomic cation-selective channel activity  
enables acetylcholine-gated monoatomic cation-selective channel activity PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity  
enables acetylcholine-gated monoatomic cation-selective channel activity PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity  
enables adenylate cyclase binding PubMed 
enables amyloid-beta binding  
enables chloride channel regulator activity  
enables monoatomic ion channel activity PubMed 
enables monoatomic ion channel activity  
enables protein binding PubMed 
enables protein homodimerization activity  
enables protein kinase binding PubMed 
enables scaffold protein binding PubMed 
enables toxic substance binding  
enables transmembrane signaling receptor activity  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
Items 1 - 25 of 118
Process Evidence Code Pubs
involved_in B cell activation  
acts_upstream_of_or_within B cell activation  
involved_in T cell activation  
acts_upstream_of_or_within T cell activation  
involved_in acetylcholine receptor signaling pathway PubMed 
involved_in associative learning  
acts_upstream_of_or_within associative learning  
involved_in behavioral response to ethanol  
acts_upstream_of_or_within behavioral response to ethanol  
involved_in behavioral response to nicotine  
acts_upstream_of_or_within behavioral response to nicotine  
acts_upstream_of_or_within calcium ion transport PubMed 
involved_in calcium ion transport  
involved_in chemical synaptic transmission  
involved_in cognition  
involved_in dendrite arborization  
involved_in dendrite arborization  
involved_in dendritic spine organization  
involved_in dendritic spine organization  
involved_in dopamine biosynthetic process PubMed 
involved_in endocytosis  
acts_upstream_of_or_within endocytosis  
involved_in establishment of localization in cell  
acts_upstream_of_or_within establishment of localization in cell  
involved_in excitatory postsynaptic potential  
involved_in excitatory postsynaptic potential  
involved_in flagellated sperm motility  
acts_upstream_of_or_within flagellated sperm motility  
involved_in generation of ovulation cycle rhythm  
acts_upstream_of_or_within generation of ovulation cycle rhythm  
involved_in intracellular calcium ion homeostasis  
involved_in learning or memory PubMed 
involved_in learning or memory  
involved_in memory PubMed 
involved_in memory  
acts_upstream_of_or_within memory  
involved_in modulation of chemical synaptic transmission  
involved_in modulation of excitatory postsynaptic potential  
involved_in monoatomic ion transmembrane transport  
involved_in monoatomic ion transmembrane transport PubMed 
involved_in monoatomic ion transmembrane transport  
involved_in monoatomic ion transmembrane transport  
acts_upstream_of_or_within monoatomic ion transport  
involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
involved_in negative regulation of amyloid-beta formation  
involved_in negative regulation of inflammatory response  
acts_upstream_of_or_within negative regulation of inflammatory response  
involved_in negative regulation of interleukin-1 beta production  
acts_upstream_of_or_within negative regulation of interleukin-1 beta production  
involved_in negative regulation of interleukin-6 production  
acts_upstream_of_or_within negative regulation of interleukin-6 production  
involved_in negative regulation of protein phosphorylation  
involved_in negative regulation of tumor necrosis factor production  
acts_upstream_of_or_within negative regulation of tumor necrosis factor production  
involved_in negative regulation of tumor necrosis factor production  
involved_in neuronal action potential PubMed 
acts_upstream_of_or_within ovulation cycle  
involved_in positive regulation of CoA-transferase activity  
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of amyloid-beta formation  
involved_in positive regulation of amyloid-beta formation  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure  
acts_upstream_of_or_within positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure  
involved_in positive regulation of long-term synaptic potentiation  
involved_in positive regulation of long-term synaptic potentiation  
involved_in positive regulation of peptidyl-serine phosphorylation  
involved_in positive regulation of protein metabolic process  
involved_in positive regulation of protein phosphorylation  
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in regulation of amyloid fibril formation  
involved_in regulation of amyloid fibril formation  
involved_in regulation of amyloid precursor protein catabolic process  
acts_upstream_of_or_within regulation of inflammatory response  
involved_in regulation of membrane potential  
acts_upstream_of_or_within regulation of membrane potential PubMed 
acts_upstream_of_or_within regulation of membrane potential PubMed 
acts_upstream_of_or_within regulation of membrane potential  
involved_in regulation of norepinephrine secretion  
acts_upstream_of_or_within regulation of norepinephrine secretion  
involved_in regulation of response to drug PubMed 
involved_in regulation of synapse structural plasticity  
involved_in regulation of synapse structural plasticity  
involved_in regulation of synaptic transmission, dopaminergic  
acts_upstream_of_or_within regulation of synaptic transmission, dopaminergic  
involved_in response to acetylcholine PubMed 
involved_in response to acetylcholine  
involved_in response to amyloid-beta  
involved_in response to amyloid-beta  
involved_in response to carbamate PubMed 
involved_in response to cold  
involved_in response to cold  
acts_upstream_of_or_within response to ethanol  
involved_in response to food  
acts_upstream_of_or_within response to food  
involved_in response to hypoxia  
involved_in response to nicotine PubMed 
involved_in response to nicotine PubMed 
acts_upstream_of_or_within response to nicotine  
involved_in response to nicotine  
involved_in sensory processing PubMed 
involved_in sensory processing  
involved_in sensory processing  
involved_in signal transduction  
involved_in synapse organization  
involved_in synaptic transmission, cholinergic  
involved_in synaptic transmission, cholinergic PubMed 
acts_upstream_of_or_within synaptic transmission, cholinergic  
involved_in synaptic transmission, cholinergic  
Items 1 - 25 of 118
Items 1 - 20 of 40
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex  
part_of acetylcholine-gated channel complex PubMed 
part_of acetylcholine-gated channel complex  
part_of acetylcholine-gated channel complex PubMed 
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in asymmetric synapse PubMed 
located_in axolemma  
located_in axolemma  
located_in axon PubMed 
is_active_in cholinergic synapse PubMed 
is_active_in cholinergic synapse PubMed 
located_in cholinergic synapse  
is_active_in cholinergic synapse  
located_in dendrite PubMed 
located_in dendritic shaft PubMed 
located_in dendritic spine PubMed 
located_in external side of plasma membrane  
located_in external side of plasma membrane  
is_active_in glycinergic synapse PubMed 
is_active_in glycinergic synapse PubMed 
located_in growth cone PubMed 
located_in membrane  
is_active_in neuron projection  
located_in neuronal cell body PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane raft PubMed 
is_active_in postsynaptic membrane PubMed 
located_in postsynaptic membrane  
is_active_in postsynaptic membrane  
is_active_in postsynaptic specialization membrane PubMed 
located_in postsynaptic specialization membrane  
is_active_in postsynaptic specialization membrane  
is_active_in presynaptic membrane PubMed 
located_in presynaptic membrane PubMed 
located_in presynaptic membrane  
is_active_in presynaptic membrane  
is_active_in spine apparatus membrane PubMed 
is_active_in synapse  
Items 1 - 20 of 40

General protein information

Preferred Names
neuronal acetylcholine receptor subunit alpha-7
Names
C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
bungarotoxin alpha
cholinergic receptor, nicotinic, alpha 7 (neuronal)
cholinergic receptor, nicotinic, alpha polypeptide 7
neuronal nicotinic acetycholine receptor alpha 7
nicotinic receptor alpha 7 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012832.4NP_036964.3  neuronal acetylcholine receptor subunit alpha-7 precursor

    See identical proteins and their annotated locations for NP_036964.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q05941, Q53YK2
    UniProtKB/TrEMBL
    A0A0G2K5T5, A6JBJ4
    Related
    ENSRNOP00000073551.2, ENSRNOT00000082487.3
    Conserved Domains (3) summary
    TIGR00860
    Location:4490
    LIC; Cation transporter family protein
    pfam02931
    Location:26230
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:237486
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    126123425..126249181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281670.1XP_063137740.1  neuronal acetylcholine receptor subunit alpha-7 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5T5, Q5UMH9
    Related
    ENSRNOP00000045255.4, ENSRNOT00000051883.6
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