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Sod3 superoxide dismutase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25352, updated on 4-Jan-2025

Summary

Official Symbol
Sod3provided by RGD
Official Full Name
superoxide dismutase 3provided by RGD
Primary source
RGD:3733
See related
EnsemblRapid:ENSRNOG00000003869 AllianceGenome:RGD:3733
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ECSODPT
Summary
Enables superoxide dismutase activity. Involved in blood vessel diameter maintenance; response to copper ion; and response to oxidative stress. Located in collagen-containing extracellular matrix and extracellular space. Used to study hypertension. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 1072.7), Adrenal (RPKM 814.8) and 6 other tissues See more
Orthologs
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Genomic context

See Sod3 in Genome Data Viewer
Location:
14q11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (62822865..62828602, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (58610104..58615845, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (60958583..60971143, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481755 Neighboring gene coiled-coil domain containing 149 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC134481756

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding  
enables molecular adaptor activity  
enables superoxide dismutase activity  
enables superoxide dismutase activity PubMed 
enables superoxide dismutase activity  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in collagen-containing extracellular matrix PubMed 
located_in collagen-containing extracellular matrix  
located_in extracellular space PubMed 
located_in extracellular space  

General protein information

Preferred Names
extracellular superoxide dismutase [Cu-Zn]
Names
EC-SOD
Superoxide dimutase 3
extracellular superoxide dismutase
superoxide dismutase 3, extracellular
superoxide dismutase B
NP_037012.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012880.2NP_037012.1  extracellular superoxide dismutase [Cu-Zn] precursor

    See identical proteins and their annotated locations for NP_037012.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q08420, Q64667
    UniProtKB/TrEMBL
    A6IJH8
    Related
    ENSRNOP00000101578.1, ENSRNOT00000158055.1
    Conserved Domains (1) summary
    pfam00080
    Location:84217
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    62822865..62828602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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