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Tmpo thymopoietin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25359, updated on 13-Apr-2024

Summary

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Official Symbol
Tmpoprovided by RGD
Official Full Name
thymopoietinprovided by RGD
Primary source
RGD:3875
See related
Ensembl:ENSRNOG00000008797 AllianceGenome:RGD:3875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LAP2
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within regulation of transcription, DNA-templated. Located in nuclear inner membrane. Orthologous to human TMPO (thymopoietin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 428.2), Spleen (RPKM 312.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmpo in Genome Data Viewer
Location:
7q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (27529977..27554980, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (25642752..25667756, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (31847412..31872416, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene IKBKB interacting protein Neighboring gene solute carrier family 25 member 3 Neighboring gene small nucleolar RNA, H/ACA box 53 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene uncharacterized LOC134479859 Neighboring gene transfer RNA tryptophan (anticodon CCA) 1 Neighboring gene transfer RNA aspartic acid (anticodon GUC) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope. Furukawa K, et al. EMBO J, 1995 Apr 18. PMID 7737115, Free PMC Article
  2. Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina. Bradley CM, et al. Structure, 2007 Jun. PMID 17562312
  3. Lap2alpha expression is controlled by E2F and deregulated in various human tumors. Parise P, et al. Cell Cycle, 2006 Jun. PMID 16760672
  4. Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. Yang L, et al. J Cell Biol, 1997 Jun 16. PMID 9182656, Free PMC Article
  5. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. Dechat T, et al. J Cell Sci, 2004 Dec 1. PMID 15546916

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
    Title: LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly.
  2. In agreement with its regulation by E2F, LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate
    Title: Lap2alpha expression is controlled by E2F and deregulated in various human tumors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear membrane reassembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lamina-associated polypeptide 2, isoform beta; lamina-associated polypeptide 2
Names
TP beta
Thymopoietin (lamina associated polypeptide 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395714.1 → NP_001382643.1  lamina-associated polypeptide 2, isoform beta isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AFR4, A6IFV9
    Related
    ENSRNOP00000092044.1, ENSRNOT00000095834.1
    Conserved Domains (3) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam11560
    Location:459 → 691
    LAP2alpha; Lamina-associated polypeptide 2 alpha
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein

  2. NM_001395715.1 → NP_001382644.1  lamina-associated polypeptide 2, isoform beta isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6G2M4, A6IFV6
    Related
    ENSRNOP00000078350.1, ENSRNOT00000112365.1
    Conserved Domains (2) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein

  3. NM_012887.2 → NP_037019.1  lamina-associated polypeptide 2, isoform beta isoform 2

    See identical proteins and their annotated locations for NP_037019.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q62733
    UniProtKB/TrEMBL
    A6IFV8
    Related
    ENSRNOP00000012715.4, ENSRNOT00000012715.5
    Conserved Domains (2) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    27529977..27554980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765219.1 → XP_008763441.1  lamina-associated polypeptide 2 isoform X2

    See identical proteins and their annotated locations for XP_008763441.1

    UniProtKB/TrEMBL
    A0A8I5ZZ38, A6IFV7
    Related
    ENSRNOP00000084254.1, ENSRNOT00000097150.1
    Conserved Domains (2) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein

  2. XM_039078463.1 → XP_038934391.1  lamina-associated polypeptide 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADD0
    Related
    ENSRNOP00000090294.1, ENSRNOT00000111659.1
    Conserved Domains (2) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62733.3 GenPept UniProtKB/Swiss-Prot:Q62733

Gene LinkOut

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