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Cebpe CCAAT/enhancer binding protein epsilon [ Rattus norvegicus (Norway rat) ]

Gene ID: 25410, updated on 13-Apr-2024

Summary

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Official Symbol
Cebpeprovided by RGD
Official Full Name
CCAAT/enhancer binding protein epsilonprovided by RGD
Primary source
RGD:2329
See related
Ensembl:ENSRNOG00000014282 AllianceGenome:RGD:2329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CRP1; C/EPBe
Summary
Enables DNA binding activity and identical protein binding activity. Involved in cellular response to lipopolysaccharide and myeloid cell differentiation. Predicted to be located in nucleus. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 16.3), Lung (RPKM 5.7) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cebpe in Genome Data Viewer
Location:
15p13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32139716..32141476, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28169711..28171471, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33356119..33357517, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene apoptotic chromatin condensation inducer 1 Neighboring gene similar to human chromosome 14 open reading frame 119 Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene uncharacterized LOC120096982 Neighboring gene solute carrier family 7 member 8 Neighboring gene uncharacterized LOC134482118

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon. Lekstrom-Himes JA, et al. J Exp Med, 1999 Jun 7. PMID 10359588, Free PMC Article
  2. CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge. Lekstrom-Himes J, et al. Blood, 1999 May 1. PMID 10216107
  3. Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice. Tavor S, et al. Blood, 2002 Mar 1. PMID 11861297
  4. Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon. Gombart AF, et al. Blood, 2001 May 1. PMID 11313242
  5. Molecular studies of prion diseases. Safar J, et al. Prog Brain Res, 1998. PMID 9932423

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within macrophage differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myeloid cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within phagocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCAAT/enhancer-binding protein epsilon
Names
CCAAT/enhancer binding protein (C/EBP), epsilon
CCAAT/enhancer binding protein , epsilon
c/EBP epsilon
c/EBP-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017095.2 → NP_058791.1  CCAAT/enhancer-binding protein epsilon

    See identical proteins and their annotated locations for NP_058791.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P56261
    UniProtKB/TrEMBL
    A6KGV9
    Related
    ENSRNOP00000019154.1, ENSRNOT00000019155.4
    Conserved Domains (1) summary
    cd14715
    Location:202 → 262
    bZIP_CEBPE; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein epsilon (CEBPE): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    32139716..32141476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56261.2 GenPept UniProtKB/Swiss-Prot:P56261

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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