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Irs1 insulin receptor substrate 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25467, updated on 4-Jan-2025

Summary

Official Symbol
Irs1provided by RGD
Official Full Name
insulin receptor substrate 1provided by RGD
Primary source
RGD:2922
See related
EnsemblRapid:ENSRNOG00000014597 AllianceGenome:RGD:2922
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IRS1IRM
Summary
Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of insulin receptor signaling pathway; and regulation of peptide hormone secretion. Part of insulin receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; metabolic dysfunction-associated steatotic liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 289.3), Heart (RPKM 135.2) and 9 other tissues See more
Orthologs
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Genomic context

See Irs1 in Genome Data Viewer
Location:
9q34
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (91001137..91053959, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (83552964..83605797, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (88033668..88086488, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC102553709 Neighboring gene rhomboid domain containing 1 Neighboring gene uncharacterized LOC120094721 Neighboring gene collagen type IV alpha 4 chain

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 31
Function Evidence Code Pubs
enables SH2 domain binding PubMed 
enables insulin receptor binding  
enables insulin receptor binding  
enables insulin receptor binding PubMed 
enables insulin receptor binding  
enables insulin receptor binding  
enables insulin-like growth factor receptor binding  
enables insulin-like growth factor receptor binding PubMed 
enables insulin-like growth factor receptor binding  
enables insulin-like growth factor receptor binding  
enables phosphatidylinositol 3-kinase activator activity  
enables phosphatidylinositol 3-kinase binding  
enables phosphatidylinositol 3-kinase binding PubMed 
enables phosphatidylinositol 3-kinase binding  
enables phosphatidylinositol 3-kinase binding PubMed 
enables phosphatidylinositol 3-kinase binding PubMed 
enables phosphatidylinositol 3-kinase binding  
enables phosphotyrosine residue binding  
enables phosphotyrosine residue binding  
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables protein kinase C binding PubMed 
enables protein kinase binding PubMed 
enables protein kinase binding  
enables protein-containing complex binding PubMed 
enables protein-macromolecule adaptor activity  
enables signaling adaptor activity  
enables signaling receptor complex adaptor activity  
enables signaling receptor complex adaptor activity  
enables transmembrane receptor protein tyrosine kinase adaptor activity PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity  
Items 1 - 25 of 31
Items 1 - 25 of 51
Process Evidence Code Pubs
acts_upstream_of cell migration  
involved_in cellular response to angiotensin PubMed 
involved_in cellular response to brain-derived neurotrophic factor stimulus PubMed 
involved_in cellular response to fatty acid  
acts_upstream_of_or_within cellular response to insulin stimulus  
involved_in cellular response to insulin stimulus  
involved_in cellular response to radiation PubMed 
involved_in cytokine-mediated signaling pathway  
involved_in cytokine-mediated signaling pathway  
acts_upstream_of epithelial cell migration  
involved_in insulin receptor signaling pathway  
involved_in insulin receptor signaling pathway PubMed 
involved_in insulin receptor signaling pathway  
acts_upstream_of_or_within insulin receptor signaling pathway  
involved_in insulin receptor signaling pathway  
NOT acts_upstream_of_or_within insulin secretion  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
acts_upstream_of_or_within lipid catabolic process  
acts_upstream_of_or_within mammary gland development  
involved_in negative regulation of insulin receptor signaling pathway PubMed 
involved_in negative regulation of insulin secretion  
involved_in negative regulation of insulin secretion PubMed 
involved_in negative regulation of insulin secretion  
involved_in negative regulation of somatostatin secretion PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of D-glucose import  
involved_in positive regulation of D-glucose import  
acts_upstream_of_or_within positive regulation of epithelial cell migration  
involved_in positive regulation of fatty acid beta-oxidation  
involved_in positive regulation of fatty acid beta-oxidation  
involved_in positive regulation of glucagon secretion PubMed 
involved_in positive regulation of glucose metabolic process  
involved_in positive regulation of glycogen biosynthetic process  
involved_in positive regulation of glycogen biosynthetic process  
involved_in positive regulation of insulin receptor signaling pathway  
involved_in positive regulation of insulin receptor signaling pathway PubMed 
involved_in positive regulation of insulin receptor signaling pathway  
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphorylation PubMed 
acts_upstream_of_or_within protein localization to nucleus  
acts_upstream_of_or_within regulation of gene expression  
involved_in response to activity PubMed 
involved_in response to caffeine PubMed 
involved_in response to caffeine PubMed 
involved_in response to ethanol PubMed 
involved_in response to insulin  
Items 1 - 25 of 51
Component Evidence Code Pubs
located_in caveola  
located_in caveola  
located_in ciliary basal body  
located_in cytoplasm  
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in cytosol  
located_in cytosol  
part_of insulin receptor complex PubMed 
located_in intracellular membrane-bounded organelle  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  
located_in nucleus  
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
insulin receptor substrate 1
Names
IRS-1
pp185

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012969.2NP_037101.2  insulin receptor substrate 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P35570
    UniProtKB/TrEMBL
    A6JW94, G3V7V7
    Related
    ENSRNOP00000101528.1, ENSRNOT00000144395.1
    Conserved Domains (2) summary
    cd01204
    Location:155258
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:11118
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    91001137..91053959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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