Myo1e myosin IE [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo1eprovided by RGD
Official Full Name: myosin IEprovided by RGD
Primary source: RGD:3144
See related: Ensembl:ENSRNOG00000061928 AllianceGenome:RGD:3144
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MYR5; Myr3
Summary: Predicted to enable several functions, including actin filament binding activity; calmodulin binding activity; and microfilament motor activity. Predicted to be involved in several processes, including glomerular filtration; glomerulus development; and vesicle transport along actin filament. Predicted to act upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; post-embryonic hemopoiesis; and vasculogenesis. Located in cuticular plate. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 162.5), Spleen (RPKM 132.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (79768828..79961048)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (70887934..71080180)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (76644715..76840240)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo1e found in hair cells of auditory and vestibular epithelia; enriched in cuticular plate, actin meshwork that anchors stereocilia.
Title: Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132530 (e-PCR)
- UniSTS:215813

D8Got203 (e-PCR)
- UniSTS:111709

AU028747 (e-PCR)
- UniSTS:112026

D8Rat195 (e-PCR), detects polymorphism
- UniSTS:228262

STS-Z41090 (e-PCR)
- UniSTS:39103

AU049451 (e-PCR)
- UniSTS:145898

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular basement membrane development	ISO Inferred from Sequence Orthology more info
involved_in glomerular basement membrane development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in glomerular filtration	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerulus development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in podocyte development	ISO Inferred from Sequence Orthology more info
involved_in podocyte development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within post-embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cuticular plate	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unconventional myosin-Ie

Names: Unconventional myosin from rat 5; myosin heavy chain myr 3; myosin-Ie; unconventional myosin 1E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173101.2 → NP_775124.1 unconventional myosin-Ie

See identical proteins and their annotated locations for NP_775124.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q63356

UniProtKB/TrEMBL

A0A0G2K9E8

Related

ENSRNOP00000083425.1, ENSRNOT00000104863.1

Conserved Domains (4) summary

cd11827
Location:1055 → 1106

SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins

smart00242
Location:14 → 692

MYSc; Myosin. Large ATPases

cd01378
Location:33 → 679

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:719 → 899

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

79768828..79961048

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080888.2 → XP_038936816.1 unconventional myosin-Ie isoform X1

UniProtKB/TrEMBL

A0A0G2K9E8

Related

ENSRNOP00000074970.2

Conserved Domains (3) summary

cd11827
Location:961 → 1012

SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins

cd01378
Location:1 → 585

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:625 → 826

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding