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Pcsk6 proprotein convertase subtilisin/kexin type 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25507, updated on 2-May-2024

Summary

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Official Symbol
Pcsk6provided by RGD
Official Full Name
proprotein convertase subtilisin/kexin type 6provided by RGD
Primary source
RGD:3246
See related
Ensembl:ENSRNOG00000011526 AllianceGenome:RGD:3246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Spc4; Pace4
Summary
Predicted to enable heparin binding activity; nerve growth factor binding activity; and serine-type endopeptidase activity. Involved in peptide hormone processing. Predicted to be active in several cellular components, including cell surface; collagen-containing extracellular matrix; and extracellular space. Orthologous to human PCSK6 (proprotein convertase subtilisin/kexin type 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 199.7), Liver (RPKM 95.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pcsk6 in Genome Data Viewer
Location:
1q22
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (128839742..129038087)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (119428978..119627626)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (126749508..126947392)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547214 Neighboring gene uncharacterized LOC102549305 Neighboring gene ribosomal protein S29, pseudogene 9 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene selenoprotein S

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of pro-protein convertase subtilisin/kexin type 6 has a protective role against synovitis in a rat model of rheumatoid arthritis. Jiang H, et al. Mol Med Rep, 2015 Nov. PMID 26458419
  2. Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland. Akamatsu T, et al. Dev Dyn, 2007 Jan. PMID 17083113
  3. Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland. Akamatsu T, et al. Dev Biol, 2009 Jan 15. PMID 19013448
  4. Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix. Tsuji A, et al. Biochim Biophys Acta, 2003 Jan 31. PMID 12535616
  5. Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4). Nagahama M, et al. FEBS Lett, 1998 Aug 28. PMID 9738469

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCSK6 knockdown significantly decreased the cell proliferation, invasion and migration of fibroblastlike synoviocytes from rats with collageninduced arthritis.
    Title: Inhibition of pro-protein convertase subtilisin/kexin type 6 has a protective role against synovitis in a rat model of rheumatoid arthritis.
  2. PACE4 regulates the SMG development via the activation of some growth/differentiation factors.
    Title: Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland.
  3. temporospatially regulated expression of PACE4 suggests its apparent association with the proliferation, differentiation, and establishment of functional acinar and ductal cells of the submandibular gland.
    Title: Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland.
  4. Selective and transient association of RCN-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4.
    Title: A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables nerve growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nerve growth factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in nerve growth factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide hormone processing IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide hormone processing IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in peptide hormone processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in secretion by cell IEA
Inferred from Electronic Annotation
more info
  
involved_in secretion by cell ISO
Inferred from Sequence Orthology
more info
  
involved_in zygotic determination of anterior/posterior axis, embryo IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within zygotic determination of anterior/posterior axis, embryo ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proprotein convertase subtilisin/kexin type 6
Names
Subtilisin - like endoprotease
kexin-like protease PC7A
paired basic amino acid cleaving enzyme 4
subtilisin-like proprotein convertase 4
subtilisin/kexin-like protease PACE4
NP_037131.2
XP_038957724.1
XP_038957726.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012999.2 → NP_037131.2  proprotein convertase subtilisin/kexin type 6 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q63415
    UniProtKB/TrEMBL
    F1LNB4
    Related
    ENSRNOP00000015845.8, ENSRNOT00000015845.8
    Conserved Domains (7) summary
    cd04059
    Location:141 → 435
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:812 → 854
    FU; Furin-like repeats
    cd00064
    Location:768 → 813
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:520 → 610
    P_proprotein; Proprotein convertase P-domain
    pfam08686
    Location:910 → 933
    PLAC; PLAC (protease and lacunin) domain
    pfam14843
    Location:662 → 772
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:56 → 132
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    128839742..129038087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101796.2 → XP_038957724.1  proprotein convertase subtilisin/kexin type 6 isoform X1

    UniProtKB/Swiss-Prot
    Q63415
    UniProtKB/TrEMBL
    A0A8I5ZLS8
    Related
    ENSRNOP00000078906.1
    Conserved Domains (7) summary
    cd04059
    Location:141 → 435
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:825 → 867
    FU; Furin-like repeats
    cd00064
    Location:781 → 826
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:520 → 610
    P_proprotein; Proprotein convertase P-domain
    pfam08686
    Location:923 → 946
    PLAC; PLAC (protease and lacunin) domain
    pfam14843
    Location:675 → 785
    GF_recep_IV; Growth factor receptor domain IV
    pfam16470
    Location:56 → 132
    S8_pro-domain; Peptidase S8 pro-domain

  2. XM_039101798.2 → XP_038957726.1  proprotein convertase subtilisin/kexin type 6 isoform X2

    UniProtKB/TrEMBL
    A6JBN6
    Conserved Domains (6) summary
    cd04059
    Location:2 → 215
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    smart00261
    Location:605 → 647
    FU; Furin-like repeats
    cd00064
    Location:561 → 606
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam01483
    Location:300 → 390
    P_proprotein; Proprotein convertase P-domain
    pfam08686
    Location:703 → 726
    PLAC; PLAC (protease and lacunin) domain
    pfam14843
    Location:455 → 565
    GF_recep_IV; Growth factor receptor domain IV
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63415.1 GenPept UniProtKB/Swiss-Prot:Q63415

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