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Pou1f1 POU class 1 homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25517, updated on 4-Jan-2025

Summary

Official Symbol
Pou1f1provided by RGD
Official Full Name
POU class 1 homeobox 1provided by RGD
Primary source
RGD:3367
See related
EnsemblRapid:ENSRNOG00000000715 AllianceGenome:RGD:3367
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GHF1; Pit1; GHF1A; PIT1Z
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and lncRNA binding activity. Involved in adenohypophysis development; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in chromatin. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 2.5), Kidney (RPKM 2.4) and 9 other tissues See more
Orthologs
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Genomic context

See Pou1f1 in Genome Data Viewer
Location:
11p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (16763312..16781295)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (3316818..3334804)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (2645659..2662581)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene geminin, pseudogene 1 Neighboring gene uncharacterized LOC134480943 Neighboring gene uncharacterized LOC134480945 Neighboring gene charged multivesicular body protein 2B Neighboring gene uncharacterized LOC134480944

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding  
enables DNA binding  
enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding  
enables chromatin binding  
enables lncRNA binding PubMed 
enables protein binding PubMed 
enables sequence-specific DNA binding  
enables sequence-specific double-stranded DNA binding  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation  
involved_in adenohypophysis development PubMed 
acts_upstream_of_or_within cell fate specification  
acts_upstream_of cell population proliferation  
acts_upstream_of_or_within determination of adult lifespan  
acts_upstream_of inositol trisphosphate biosynthetic process  
involved_in negative regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within pituitary gland development  
involved_in positive regulation of DNA-templated transcription PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription  
acts_upstream_of_or_within positive regulation of cell population proliferation  
acts_upstream_of_or_within positive regulation of inositol trisphosphate biosynthetic process  
acts_upstream_of_or_within positive regulation of multicellular organism growth  
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of DNA-templated transcription  
acts_upstream_of_or_within regulation of insulin-like growth factor receptor signaling pathway  
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within somatotropin secreting cell development  
acts_upstream_of_or_within somatotropin secreting cell differentiation  
Component Evidence Code Pubs
located_in chromatin PubMed 
located_in cytosol  
located_in cytosol  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
pituitary-specific positive transcription factor 1
Names
GHF-1
POU domain, class 1, transcription factor 1
Pituary specific transcription factor 1 (growth hormone factor 1)
growth hormone factor 1
homeodomain protein for Growth Hormone (GH)
pit-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013008.3NP_037140.2  pituitary-specific positive transcription factor 1

    See identical proteins and their annotated locations for NP_037140.2

    Status: PROVISIONAL

    Source sequence(s)
    BC061563
    UniProtKB/TrEMBL
    Q6P7Q7, Q6P7Q8
    Conserved Domains (2) summary
    smart00352
    Location:124198
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:217270
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    16763312..16781295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247974.2XP_006248036.1  pituitary-specific positive transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006248036.1

    UniProtKB/TrEMBL
    A6K4W6, Q6P7Q7
    Related
    ENSRNOP00000000905.6, ENSRNOT00000000905.8
    Conserved Domains (2) summary
    smart00352
    Location:150224
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:243297
    Homeobox; Homeobox domain
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