Fabp2 fatty acid binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fabp2provided by RGD
Official Full Name: fatty acid binding protein 2provided by RGD
Primary source: RGD:2591
See related: Ensembl:ENSRNOG00000024947 AllianceGenome:RGD:2591
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FABP
Summary: Enables long-chain fatty acid binding activity and long-chain fatty acid transporter activity. Involved in fatty acid metabolic process; intestinal absorption; and long-chain fatty acid transport. Located in apical cortex; microvillus; and plasma membrane. Human ortholog(s) of this gene implicated in alcoholic liver cirrhosis; carotid stenosis; coronary artery disease; end stage renal disease; and obesity. Orthologous to human FABP2 (fatty acid binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 54.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (213724629..213728686)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (211040032..211044089)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (227080912..227083654)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The importance of serum intestinal fatty acid-binding protein for the early diagnosis of acute mesenteric ischemia.", trans "Akut mezenter iskeminin erken tanisinda serum intestinal yag asidi baglayici proteininin onemi.
Title: The importance of serum intestinal fatty acid-binding protein for the early diagnosis of acute mesenteric ischemia.
In acute mesenteric ischemia, Fabp2 levels are significantly increased and correlated with ischemic changes.
Title: Comparison of the diagnostic values of vascular adhesion protein-1 and intestinal fatty acid-binding protein in the diagnosis of acute mesenteric ischemia.
The aim of this experimental study was to determine if the type of termino-terminal anastomosis of the colon affect the process of healing of the intestinal mucosa and if the severity of the anastomotic leakage (AL) can be predicted based on the circulating level of intestinal fatty acid-binding protein.
Title: Intestinal fatty acid-binding protein, as a marker of anastomotic leakage after colonic resection in rats.
Study characterized internal-water exchange and associated conformational dynamics in rIFABP by recording the water 2H and 17O MRD profiles for the apo and palmitate-bound forms
Title: Time Scales of Conformational Gating in a Lipid-Binding Protein.
This work highlights the importance of the beta-barrel of IFABP for its specific functions.
Title: Characterization of fatty acid binding and transfer from Δ98Δ, a functional all-β abridged form of IFABP.
the portal region of IFABP penetrates deeply into the phospholipid bilayer, especially when CL-containing vesicles are employed. The orientation of the protein and the degree of penetration were highly dependent on the lipid composition
Title: IFABP portal region insertion during membrane interaction depends on phospholipid composition.
n-3 PUFAs protect the intestinal barrier by modifying intracellular I-FABP, activating the PPARgamma pathway, and then upregulating tight junction protein expression.
Title: N-3 PUFAs attenuate ischemia/reperfusion induced intestinal barrier injury by activating I-FABP-PPARγ pathway.
Conjugated linoleic acid can improve insulin resistance of obese rat and increase the expression of fatty acid binding protein 2 mRNA.
Title: [Effect of conjugated linoleic acid on the gene expression of the fatty acid binding proteins in resistant rat].
Delta 78 Delta beta-barrel motif retains substantial beta-sheet content and preserves tertiary interactions, displaying cooperative unfolding and binding activity. Most strikingly, this construct adopts a remarkably stable dimeric structure in solution.
Title: Dissection of a beta-barrel motif leads to a functional dimer: the case of the intestinal fatty acid binding protein.
A structural explanation of the observed affinity of rat I-FABP for different drugs based on spectroscopic data and modeling experiments is presented.immunocytochemistry has been used to probe the expression of I-FABP in a cell culture model.
Title: Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Markers

PMC61071P2 (e-PCR)
- UniSTS:273408

RH94797 (e-PCR)
- UniSTS:120044

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables fatty acid binding	TAS Traceable Author Statement more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in intestinal absorption	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal lipid absorption	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid-binding protein, intestinal

Names: FABPI; I-FABP; fatty acid binding protein 1; fatty acid binding protein 2, intestinal; intestinal fatty acid binding protein; intestinal-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.