Igfbp6 insulin-like growth factor binding protein 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igfbp6provided by RGD
Official Full Name: insulin-like growth factor binding protein 6provided by RGD
Primary source: RGD:2877
See related: Ensembl:ENSRNOG00000010977 AllianceGenome:RGD:2877
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RBP6A; RBP6G; IGF-BP6
Summary: Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in cell migration; positive regulation of stress-activated MAPK cascade; and regulation of insulin-like growth factor receptor signaling pathway. Located in Golgi apparatus and extracellular space. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP6 (insulin like growth factor binding protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 1152.5), Muscle (RPKM 657.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (135154919..135159550)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (133276309..133280944)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (143749385..143754018)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IGFBP-6 was significantly up-regulated adjacent to the hematoma following intracerebral hemorrhage.
Title: Insulin-like Growth Factor Binding Protein6 Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage in Rats.
Following spinal cord injury, IGFBP6 was significantly up-regulated.
Title: The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis.
IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation.
Title: Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.
Toxic effect of TCDD on osteogenesis through altering Igfbp6 gene expression in osteoblasts is reported.
Title: Toxic effects of TCDD on osteogenesis through altering IGFBP-6 gene expression in osteoblasts.
IGFBP6 has a role in binding to endothelial cells and in transendothelial transportation
Title: Structure-function relationships of insulin-like growth factor binding protein 6 (IGFBP-6) and its chimeras.
IGFBP-6, a new negative effector of oligodendrocyte survival and differentiation, is expressed and localized to the Golgi complex in rat oligodendrocyte precursor (O2A) cells.
Title: Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells.

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General gene information

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Markers

D7Wox40 (e-PCR)
- UniSTS:239386

RH131180 (e-PCR)
- UniSTS:214463

RH94790 (e-PCR)
- UniSTS:120037

BF404305 (e-PCR)
- UniSTS:247030

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor II binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of insulin-like growth factor binary complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 6

Names: IBP-6; IGF-binding protein 6; IGFBP-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013104.3 → NP_037236.1 insulin-like growth factor-binding protein 6 precursor

See identical proteins and their annotated locations for NP_037236.1

Status: PROVISIONAL

Source sequence(s)

M69055

UniProtKB/Swiss-Prot

P35572, Q499W1

UniProtKB/TrEMBL

A6KCS9

Related

ENSRNOP00000014807.3, ENSRNOT00000014807.7

Conserved Domains (2) summary

smart00121
Location:28 → 97

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:148 → 220

Thyroglobulin_1; Thyroglobulin type-1 repeat