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Bmp6 bone morphogenetic protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25644, updated on 4-Jan-2025

Summary

Official Symbol
Bmp6provided by RGD
Official Full Name
bone morphogenetic protein 6provided by RGD
Primary source
RGD:2214
See related
EnsemblRapid:ENSRNOG00000013717 AllianceGenome:RGD:2214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
VGR
Summary
Enables growth factor activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of aldosterone secretion; and positive regulation of cell differentiation. Located in extracellular space and vesicle. Biomarker of anemia; brain ischemia; and colitis. Orthologous to human BMP6 (bone morphogenetic protein 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 273.0), Heart (RPKM 77.7) and 5 other tissues See more
Orthologs
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Genomic context

See Bmp6 in Genome Data Viewer
Location:
17p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (26523704..26785558, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (26318121..26469691, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (26955142..27112820, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482844 Neighboring gene thioredoxin domain containing 5 Neighboring gene U6 spliceosomal RNA Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 48

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables BMP receptor binding  
enables cytokine activity  
enables growth factor activity PubMed 
enables protein heterodimerization activity  
Items 1 - 25 of 48
Process Evidence Code Pubs
involved_in BMP signaling pathway  
acts_upstream_of_or_within BMP signaling pathway  
involved_in BMP signaling pathway  
involved_in bone development  
involved_in cartilage development  
involved_in cellular response to BMP stimulus  
involved_in cellular response to iron ion  
involved_in cellular response to mechanical stimulus PubMed 
acts_upstream_of_or_within endochondral ossification  
involved_in eye development  
involved_in immune response  
involved_in inflammatory response  
acts_upstream_of_or_within intracellular iron ion homeostasis  
involved_in intracellular iron ion homeostasis  
involved_in kidney development  
acts_upstream_of_or_within male genitalia development  
involved_in multicellular organismal-level iron ion homeostasis  
involved_in multicellular organismal-level iron ion homeostasis  
involved_in negative regulation of adherens junction organization  
involved_in negative regulation of cell-cell adhesion mediated by cadherin  
involved_in negative regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within neuron differentiation  
involved_in ossification PubMed 
involved_in osteoblast differentiation PubMed 
acts_upstream_of_or_within osteoblast differentiation  
involved_in positive regulation of SMAD protein signal transduction  
involved_in positive regulation of aldosterone biosynthetic process  
involved_in positive regulation of aldosterone secretion PubMed 
involved_in positive regulation of bone mineralization  
involved_in positive regulation of chondrocyte differentiation PubMed 
involved_in positive regulation of endothelial cell differentiation  
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of epithelial cell proliferation  
involved_in positive regulation of gene expression  
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway  
acts_upstream_of_or_within positive regulation of neuron differentiation  
involved_in positive regulation of osteoblast differentiation PubMed 
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of vascular permeability  
involved_in regulation of cell differentiation PubMed 
involved_in response to activity PubMed 
involved_in response to glucocorticoid PubMed 
involved_in response to iron ion PubMed 
involved_in response to magnesium ion PubMed 
involved_in response to retinoic acid PubMed 
involved_in type B pancreatic cell development  
Items 1 - 25 of 48
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
located_in vesicle PubMed 

General protein information

Preferred Names
bone morphogenetic protein 6
Names
BMP-6
VG-1-related protein
VGR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013107.2NP_037239.1  bone morphogenetic protein 6 precursor

    See identical proteins and their annotated locations for NP_037239.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q04906, Q811S4
    UniProtKB/TrEMBL
    A6J7A4, A6J7A5
    Related
    ENSRNOP00000018359.5, ENSRNOT00000018359.9
    Conserved Domains (2) summary
    smart00204
    Location:405506
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:58355
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    26523704..26785558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276108.1XP_063132178.1  bone morphogenetic protein 6 isoform X3

  2. XM_063276107.1XP_063132177.1  bone morphogenetic protein 6 isoform X3

  3. XM_063276110.1XP_063132180.1  bone morphogenetic protein 6 isoform X5

  4. XM_063276106.1XP_063132176.1  bone morphogenetic protein 6 isoform X2

  5. XM_039095387.2XP_038951315.1  bone morphogenetic protein 6 isoform X1

    UniProtKB/TrEMBL
    A6J7A5
    Conserved Domains (2) summary
    cd19396
    Location:404535
    TGF_beta_BMP6; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins
    pfam00688
    Location:58355
    TGFb_propeptide; TGF-beta propeptide
  6. XM_063276109.1XP_063132179.1  bone morphogenetic protein 6 isoform X4

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