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Adrb3 adrenoceptor beta 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25645, updated on 4-Jan-2025

Summary

Official Symbol
Adrb3provided by RGD
Official Full Name
adrenoceptor beta 3provided by RGD
Primary source
RGD:2061
See related
EnsemblRapid:ENSRNOG00000012674 AllianceGenome:RGD:2061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ADRB
Summary
Enables epinephrine binding activity and norepinephrine binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and eating behavior. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of colitis; congestive heart failure; and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 47.1), Thymus (RPKM 41.3) and 4 other tissues See more
Orthologs
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Genomic context

See Adrb3 in Genome Data Viewer
Location:
16q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (71544603..71547410)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (64839820..64844552)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (69003541..69006632)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene testis expressed gene 24 like Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene RAB11 family interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-3 adrenergic receptor binding  
enables beta-adrenergic receptor activity  
enables beta-adrenergic receptor activity  
enables beta3-adrenergic receptor activity  
enables beta3-adrenergic receptor activity  
enables beta3-adrenergic receptor activity  
enables epinephrine binding  
enables epinephrine binding PubMed 
enables norepinephrine binding PubMed 
contributes_to norepinephrine binding  
contributes_to norepinephrine binding  
enables protein homodimerization activity  
enables protein homodimerization activity  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
acts_upstream_of_or_within brown fat cell differentiation  
acts_upstream_of_or_within diet induced thermogenesis  
involved_in eating behavior PubMed 
acts_upstream_of_or_within heat generation  
NOT involved_in negative regulation of G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within negative regulation of multicellular organism growth  
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of cold-induced thermogenesis  
involved_in positive regulation of cold-induced thermogenesis PubMed 
NOT involved_in receptor-mediated endocytosis  
acts_upstream_of_or_within response to cold  
Component Evidence Code Pubs
located_in membrane  
is_active_in plasma membrane  
part_of receptor complex  
part_of receptor complex  

General protein information

Preferred Names
beta-3 adrenergic receptor
Names
adrenergic receptor, beta 3
adrenergic, beta-3-, receptor
beta-3 adrenoceptor
beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013108.2NP_037240.2  beta-3 adrenergic receptor

    See identical proteins and their annotated locations for NP_037240.2

    Status: VALIDATED

    Source sequence(s)
    BQ189922, JAXUCZ010000016, M74716
    UniProtKB/Swiss-Prot
    P26255
    UniProtKB/TrEMBL
    A6IVX3
    Related
    ENSRNOP00000016907.3, ENSRNOT00000016907.4
    Conserved Domains (2) summary
    pfam00001
    Location:51343
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51145
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    71544603..71547410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771315.4XP_008769537.1  beta-3 adrenergic receptor isoform X1

    See identical proteins and their annotated locations for XP_008769537.1

    UniProtKB/TrEMBL
    A6IVX2, A6IVX3
    Conserved Domains (2) summary
    pfam00001
    Location:72364
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:72166
    7tm_4; Olfactory receptor
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