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Selp selectin P [ Rattus norvegicus (Norway rat) ]

Gene ID: 25651, updated on 4-Jan-2025

Summary

Official Symbol
Selpprovided by RGD
Official Full Name
selectin Pprovided by RGD
Primary source
RGD:3656
See related
EnsemblRapid:ENSRNOG00000002794 AllianceGenome:RGD:3656
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PSELECT
Summary
Predicted to enable several functions, including fucose binding activity; heparin binding activity; and lipopolysaccharide binding activity. Involved in several processes, including leukocyte migration; regulation of cellular extravasation; and response to lipopolysaccharide. Located in external side of plasma membrane and extracellular space. Used to study acute necrotizing pancreatitis and anti-basement membrane glomerulonephritis. Biomarker of atherosclerosis; colitis; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 50.5), Uterus (RPKM 16.2) and 8 other tissues See more
Orthologs
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Genomic context

See Selp in Genome Data Viewer
Location:
13q23
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (79009379..79044994)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76476229..76511846)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82428914..82464629)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 8, pseudogene 1 Neighboring gene selectin L Neighboring gene uncharacterized LOC134481524 Neighboring gene coagulation factor V Neighboring gene solute carrier family 19 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC124632

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium ion binding  
enables calcium ion binding  
enables calcium-dependent protein binding  
enables calcium-dependent protein binding  
enables carbohydrate binding  
enables fucose binding  
enables fucose binding  
enables heparin binding  
enables heparin binding  
enables integrin binding  
enables integrin binding  
enables integrin binding  
enables lipopolysaccharide binding  
enables lipopolysaccharide binding  
enables metal ion binding  
enables oligosaccharide binding  
enables oligosaccharide binding  
enables oligosaccharide binding  
enables oligosaccharide binding  
enables sialic acid binding  
enables sialic acid binding  
enables sialic acid binding  
Items 1 - 25 of 38
Process Evidence Code Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in cell adhesion  
involved_in cell-cell adhesion PubMed 
involved_in cell-cell adhesion  
involved_in cell-cell adhesion  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in inflammatory response  
acts_upstream_of_or_within inflammatory response  
acts_upstream_of_or_within leukocyte cell-cell adhesion  
involved_in leukocyte cell-cell adhesion  
involved_in leukocyte migration PubMed 
acts_upstream_of leukocyte migration  
acts_upstream_of_or_within leukocyte migration  
involved_in leukocyte tethering or rolling  
involved_in leukocyte tethering or rolling  
acts_upstream_of_or_within leukocyte tethering or rolling  
involved_in leukocyte tethering or rolling  
involved_in leukocyte tethering or rolling  
involved_in positive regulation of cell adhesion PubMed 
involved_in positive regulation of leukocyte migration  
acts_upstream_of_or_within positive regulation of leukocyte migration  
involved_in positive regulation of leukocyte tethering or rolling  
involved_in positive regulation of leukocyte tethering or rolling  
involved_in positive regulation of leukocyte tethering or rolling  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of platelet activation  
involved_in positive regulation of platelet activation  
involved_in regulation of cellular extravasation PubMed 
involved_in regulation of integrin activation  
involved_in regulation of integrin activation  
involved_in response to cytokine  
involved_in response to lipopolysaccharide PubMed 
involved_in response to organic cyclic compound PubMed 
Items 1 - 25 of 38
Component Evidence Code Pubs
is_active_in external side of plasma membrane  
located_in external side of plasma membrane PubMed 
located_in external side of plasma membrane  
located_in external side of plasma membrane  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
located_in extracellular space  
located_in membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in platelet alpha granule membrane  
located_in platelet alpha granule membrane  

General protein information

Preferred Names
P-selectin
Names
CD62 antigen-like family member P
GMP-140
LECAM3
PADGEM
granule membrane protein 140
leukocyte-endothelial cell adhesion molecule 3
platelet activation dependent granule-external membrane protein
selectin, platelet

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013114.2NP_037246.2  P-selectin precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    F1LNV1, Q3MID1
    Related
    ENSRNOP00000003759.4, ENSRNOT00000003759.6
    Conserved Domains (4) summary
    cd00033
    Location:200258
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:276505
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    79009379..79044994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250150.5XP_006250212.1  P-selectin isoform X1

    UniProtKB/TrEMBL
    Q3MID1
    Conserved Domains (4) summary
    cd00033
    Location:262320
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:443699
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
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