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Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25675, updated on 4-Jan-2025

Summary

Official Symbol
Hmgcrprovided by RGD
Official Full Name
3-hydroxy-3-methylglutaryl-CoA reductaseprovided by RGD
Primary source
RGD:2803
See related
EnsemblRapid:ENSRNOG00000016122 AllianceGenome:RGD:2803
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
3H3M
Summary
Enables identical protein binding activity and protein phosphatase 2A binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 107.6), Brain (RPKM 101.7) and 9 other tissues See more
Orthologs
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Genomic context

See Hmgcr in Genome Data Viewer
Location:
2q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (29732163..29754276, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (27997523..28018983, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (27480224..27500654, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase kappa Neighboring gene ceramide transporter 1 Neighboring gene ankyrin repeat domain 31 Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene chromobox 3, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase regulator activity  
enables GTPase regulator activity  
enables NADP binding  
enables NADPH binding  
enables NADPH binding  
enables coenzyme A binding  
enables coenzyme A binding  
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity  
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity  
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity  
enables identical protein binding PubMed 
enables protein phosphatase 2A binding PubMed 
Items 1 - 25 of 38
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process  
acts_upstream_of_or_within cholesterol biosynthetic process  
involved_in cholesterol biosynthetic process  
involved_in cholesterol homeostasis PubMed 
involved_in coenzyme A metabolic process  
involved_in isoprenoid biosynthetic process  
involved_in isoprenoid biosynthetic process  
involved_in long-term synaptic potentiation  
acts_upstream_of_or_within long-term synaptic potentiation  
involved_in myoblast differentiation PubMed 
acts_upstream_of_or_within negative regulation of MAP kinase activity  
involved_in negative regulation of amyloid-beta clearance  
involved_in negative regulation of amyloid-beta clearance  
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
involved_in negative regulation of protein catabolic process  
involved_in negative regulation of protein catabolic process  
involved_in negative regulation of protein secretion  
involved_in negative regulation of protein secretion  
involved_in negative regulation of striated muscle cell apoptotic process PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of skeletal muscle tissue development PubMed 
involved_in positive regulation of smooth muscle cell proliferation PubMed 
involved_in positive regulation of stress-activated MAPK cascade PubMed 
involved_in positive regulation of vasoconstriction PubMed 
involved_in regulation of ERK1 and ERK2 cascade  
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade  
involved_in response to cholesterol PubMed 
involved_in response to ethanol PubMed 
involved_in response to nutrient PubMed 
involved_in response to nutrient levels PubMed 
involved_in sterol biosynthetic process  
involved_in triglyceride homeostasis PubMed 
involved_in ubiquinone metabolic process PubMed 
involved_in visual learning  
acts_upstream_of_or_within visual learning  
Items 1 - 25 of 38
Component Evidence Code Pubs
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
is_active_in peroxisomal membrane  
located_in peroxisomal membrane  
located_in peroxisomal membrane  
located_in peroxisomal membrane  

General protein information

Preferred Names
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Names
HMG-CoA reductase
NP_037266.2
XP_006231888.1
XP_063137446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013134.2NP_037266.2  3-hydroxy-3-methylglutaryl-coenzyme A reductase

    See identical proteins and their annotated locations for NP_037266.2

    Status: PROVISIONAL

    Source sequence(s)
    BC064654
    UniProtKB/Swiss-Prot
    P51639, Q64601, Q6P2A6
    UniProtKB/TrEMBL
    A0A8L2QCN8, A6I512
    Related
    ENSRNOP00000096084.2, ENSRNOT00000101787.2
    Conserved Domains (3) summary
    cd00643
    Location:464870
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    TIGR00920
    Location:1887
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    cl21543
    Location:88218
    MMPL; MMPL family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    29732163..29754276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281376.1XP_063137446.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X2

    UniProtKB/TrEMBL
    A0A8I6AV02, A0A8L2QCN8
    Related
    ENSRNOP00000097467.1, ENSRNOT00000096437.2
  2. XM_006231826.5XP_006231888.1  3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8I6AUL2, A0A8L2QCN8
    Related
    ENSRNOP00000087297.2, ENSRNOT00000112347.2
    Conserved Domains (3) summary
    cd00643
    Location:474880
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    TIGR00920
    Location:11897
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    cl21543
    Location:98228
    MMPL; MMPL family
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