Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj6provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 6provided by RGD
Primary source: RGD:2959
See related: Ensembl:ENSRNOG00000001658 AllianceGenome:RGD:2959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G-protein alpha-subunit binding activity. Involved in cellular response to morphine and response to electrical stimulus. Located in several cellular components, including cell surface; dendrite; and neuronal cell body membrane. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 38.3), Heart (RPKM 5.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (47531312..47778348, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (34061702..34308758, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (35011007..35262362, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of Mitochondrial KATP Channels in the Infarct-Reducing Effect of Normobaric Hypoxia.
Title: The Role of Mitochondrial K(ATP) Channels in the Infarct-Reducing Effect of Normobaric Hypoxia.
Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1A and PPAR-gamma pathway.
Title: Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
Study is first to show direct cleavage of GIRK1 and GIRK2 subunits by caspase-3, with cleavage sites in GIRK1 (387ECLD390) and GIRK2 (349YEVD352) and suggests the possible role of caspase-3 mediated down-regulation of GIRK channel function and expression in hippocampal neuronal injury during prolonged epileptic seizures.
Title: Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.
The opening of ATP-sensitive K+ channels protects cardiomyocytes against the high glucose-induced injury and inflammation by inhibiting the ROS-TLR4-necroptosis pathway.
Title: The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
inwardly rectifying K+ channels coupled to 5-HT1A autoreceptors display pharmacological properties generally expected for neuronal GIRK channels, but different from GIRK1-GIRK2 heteromers
Title: Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
Fourteen days after axotomy, GIRK1 and GIRK2 were down-regulated in DRG neurons at the mRNA and protein levels.
Title: G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.
Data describe the developmental regulation and subcellular diversity of neuronal GIRK/Kir3 channels, and support the contention that distinct subpopulations of GIRK channels exert separable influences on neuronal excitability.
Title: Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.
Estradiol regulates dopamine-activataed GIRK channel activity in pituitary lactotrophs, regulating prolactin release during the estrous cycle.
Title: Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.
The mutant, Gbeta1(W332A) protein, although inactive, retains its ability to bind Kir3 and prevents the wild type Gbeta from activating the channel.
Title: Dominant negative effects of a Gbeta mutant on G-protein coupled inward rectifier K+ channel.
the KCNJ6 rs2070995 AA genotype association with increased opioid requirements extends from analgesia to opiate substitution therapy
Title: A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

AI412840 (e-PCR)
- UniSTS:261633

UniSTS:259101 (e-PCR)
- UniSTS:259101

Kcnj6 (e-PCR), detects polymorphism
- UniSTS:259101

UniSTS:143667 (e-PCR)
- UniSTS:143667

Kcnj6 (e-PCR), detects polymorphism
- UniSTS:143667

D14Rat111 (e-PCR)
- UniSTS:226611

RH94617 (e-PCR)
- UniSTS:119865

D11Rat97 (e-PCR), detects polymorphism
- UniSTS:226437

D11Mco6 (e-PCR)
- UniSTS:239298

RH132210 (e-PCR)
- UniSTS:215493

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein activated inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables G-protein activated inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to morphine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G protein-activated inward rectifier potassium channel 2

Names: BIR1; GIRK-2; GIRK2; KATP-2; inward rectifier K(+) channel Kir3.2; potassium channel, inwardly rectifying subfamily J member 6; potassium voltage-gated channel subfamily J member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393803.2 → NP_001380732.1 G protein-activated inward rectifier potassium channel 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P48550

UniProtKB/TrEMBL

A0A9K3Y8C1, F1LS53, Q8QZW1

Related

ENSRNOP00000059308.2, ENSRNOT00000066940.3

Conserved Domains (2) summary

pfam01007
Location:59 → 198

IRK; Inward rectifier potassium channel

pfam17655
Location:205 → 374

IRK_C; Inward rectifier potassium channel C-terminal domain
NM_013192.4 → NP_037324.1 G protein-activated inward rectifier potassium channel 2 isoform 1

See identical proteins and their annotated locations for NP_037324.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P48550

UniProtKB/TrEMBL

A0A8I6G5I5, Q54A91

Related

ENSRNOP00000079589.1, ENSRNOT00000119355.1

Conserved Domains (2) summary

pfam01007
Location:59 → 198

IRK; Inward rectifier potassium channel

pfam17655
Location:205 → 374

IRK_C; Inward rectifier potassium channel C-terminal domain