U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc35a4 solute carrier family 35, member A4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 257647, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc35a4provided by RGD
Official Full Name
solute carrier family 35, member A4provided by RGD
Primary source
RGD:628792
See related
Ensembl:ENSRNOG00000002908 AllianceGenome:RGD:628792
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plrr4; Plrr-4
Summary
Predicted to enable pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in positive regulation of translation in response to stress. Located in Golgi apparatus. Orthologous to human SLC35A4 (solute carrier family 35 member A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 183.6), Thymus (RPKM 168.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18p11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28555471..28558639)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28280483..28284610)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29505239..29509304)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene steroid receptor RNA activator 1 Neighboring gene amyloid beta precursor protein binding family B member 3 Neighboring gene SLC35A4 upstream open reading frame protein-like Neighboring gene Riken cDNA E230025N22 gene like Neighboring gene biliverdin reductase B, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning of the cDNA and mRNA expression of CLRP, a complex leucine repeat protein of the Golgi apparatus expressed by specific neurons of the rat brain. Pérez-Márquez J, et al. J Neurobiol, 2002 Aug. PMID 12124754
  2. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. Andreev DE, et al. Elife, 2015 Jan 26. PMID 25621764, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. complex leucine repeat protein (Clrp, Plrr4) of the Golgi apparatus expressed by specific neurons of the rat brain.
    Title: Cloning of the cDNA and mRNA expression of CLRP, a complex leucine repeat protein of the Golgi apparatus expressed by specific neurons of the rat brain.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC93140, MGC93141

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables pyrimidine nucleotide-sugar transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation in response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in pyrimidine nucleotide-sugar transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
probable UDP-sugar transporter protein SLC35A4
Names
PLRR-4 polymorphic leucine-rich repeat protein
complex leucine repeat protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147140.2 → NP_671481.2  probable UDP-sugar transporter protein SLC35A4

    See identical proteins and their annotated locations for NP_671481.2

    Status: PROVISIONAL

    Source sequence(s)
    BC085695
    UniProtKB/Swiss-Prot
    Q5RKL6, Q91ZR7
    UniProtKB/TrEMBL
    A6J325
    Conserved Domains (1) summary
    pfam04142
    Location:83 → 320
    Nuc_sug_transp; Nucleotide-sugar transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    28555471..28558639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZR7.2 GenPept UniProtKB/Swiss-Prot:Q91ZR7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous