Slc16a2 solute carrier family 16 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc16a2provided by RGD
Official Full Name: solute carrier family 16 member 2provided by RGD
Primary source: RGD:628608
See related: Ensembl:ENSRNOG00000002832 AllianceGenome:RGD:628608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables thyroid hormone transmembrane transporter activity. Involved in hormone transport. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 94.0), Liver (RPKM 82.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (72791096..72914299, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (68725365..68848572, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (74578600..74706068, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary.
Title: Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary.
We found that dehydration induced anorexia rats showed increased number of thyrotropin-releasing hormone (TRH) cells in caudal paraventricular hypothalamic nucleus, as well as a decreased percentage of TRH-expressing neurons that co-expressed monocarboxylate transporter-8 mRNA signal.
Title: Mct8 and trh co-expression throughout the hypothalamic paraventricular nucleus is modified by dehydration-induced anorexia in rats.
the coordinated effects of Oatp1c1, Mct8, D2 and D3 in the placental barrier may regulate both transplacental TH passage and the development of trophoblast cells during thyroid dysfunction throughout the pregnancy.
Title: Expression of organic anion transporting polypeptide 1c1 and monocarboxylate transporter 8 in the rat placental barrier and the compensatory response to thyroid dysfunction.
The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.
Title: Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents.
Prolonged cerebral ischemia causes compensatory increase of MCT8 mRNA expression on the capillary endothelial cell membranes in the lateral ventricle of rats.
Title: [Expression of monocarboxylate transporter 8 mRNA in the brain tissue of rats with cerebral ischemia].
Data report here that in addition to neuronal expression, MCT8 mRNA and protein are expressed in cerebral microvessels in rats.
Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.
cloned and identified as a very active and specific thyroid hormone transporter
Title: Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter.

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General gene information

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Markers

Slc16a2 (e-PCR), detects polymorphism
- UniSTS:526752

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables monocarboxylic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocarboxylic acid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect thyroid hormone generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: monocarboxylate transporter 8

Names: MCT 8; solute carrier family 16 (monocarboxylic acid transporters), member 2; solute carrier family 16, member 2 (monocarboxylic acid transporter 8); solute carrier family 16, member 2 (thyroid hormone transporter)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_147216.2 → NP_671749.2 monocarboxylate transporter 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

G3V9C2, Q8K1P8

UniProtKB/TrEMBL

A6IV07

Related

ENSRNOP00000042040.2, ENSRNOT00000040637.4

Conserved Domains (2) summary

cd17420
Location:106 → 504

MFS_MCT8_10; Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters

cl40703
Location:65 → 104

Trypan_PARP; Procyclic acidic repetitive protein (PARP)