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FAM98A family with sequence similarity 98 member A [ Homo sapiens (human) ]

Gene ID: 25940, updated on 5-May-2024

Summary

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Official Symbol
FAM98Aprovided by HGNC
Official Full Name
family with sequence similarity 98 member Aprovided by HGNC
Primary source
HGNC:HGNC:24520
See related
Ensembl:ENSG00000119812 AllianceGenome:HGNC:24520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables protein methyltransferase activity. Involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Predicted to be part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 38.2), brain (RPKM 16.8) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
2p22.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (33583660..33599299, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (33629816..33645413, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (33808727..33824366, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 4430 Neighboring gene RAS guanyl releasing protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11349 Neighboring gene RASGRP3 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:33808516-33809335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15571 Neighboring gene uncharacterized LOC105374455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15573 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:33832515-33833401 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 61

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FAM98A promotes cancer progression in endometrial carcinoma. Li Z, et al. Mol Cell Biochem, 2019 Sep. PMID 31114934
  2. A divergent calponin homology (NN-CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins. Schou KB, et al. Bioinformatics, 2014 Apr 1. PMID 24257188
  3. Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling. Wang N, et al. J Gynecol Oncol, 2022 Jan. PMID 34783205, Free PMC Article
  4. FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins. Ozeki K, et al. Mol Cell Biochem, 2019 Jan. PMID 29992460
  5. FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation. Akter KA, et al. Tumour Biol, 2016 Apr. PMID 26503212

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling.
    Title: Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling.
  2. Mechanistically, it was demonstrated that miR-142-3p directly targeted FAM98A, and modulated its expression.
    Title: FAM98A promotes cancer progression in endometrial carcinoma.
  3. the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression in colorectal cancer cell lines
    Title: FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
  4. FAM98A is expressed in numerous ovarian cancer cell lines and is important for the malignant characteristics of ovarian cancer cells.
    Title: FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with family with sequence similarity 98, member A (FAM98A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564F0522, DKFZp686O03192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA splicing, via endonucleolytic cleavage and ligation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of tRNA-splicing ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA-splicing ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
protein FAM98A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304538.2 → NP_001291467.1  protein FAM98A isoform 2

    See identical proteins and their annotated locations for NP_001291467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC017050, AK300023, BC060860, DA310995
    Consensus CDS
    CCDS92735.1
    UniProtKB/TrEMBL
    B4DT23, B4DY25
    Related
    ENSP00000510695.1, ENST00000690423.1
    Conserved Domains (1) summary
    pfam10239
    Location:2 → 132
    DUF2465; Protein of unknown function (DUF2465)

  2. NM_015475.5 → NP_056290.3  protein FAM98A isoform 1

    See identical proteins and their annotated locations for NP_056290.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC017050, BC060860, BC136768, DA310995
    Consensus CDS
    CCDS33179.1
    UniProtKB/Swiss-Prot
    B2RNA2, Q8NCA5, Q9Y3Y6
    UniProtKB/TrEMBL
    I6L9E8
    Related
    ENSP00000238823.8, ENST00000238823.13
    Conserved Domains (1) summary
    pfam10239
    Location:11 → 328
    DUF2465; Protein of unknown function (DUF2465)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    33583660..33599299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    33629816..33645413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCA5.2 GenPept UniProtKB/Swiss-Prot:Q8NCA5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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