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F7 coagulation factor VII [ Rattus norvegicus (Norway rat) ]

Gene ID: 260320, updated on 4-Jan-2025

Summary

Official Symbol
F7provided by RGD
Official Full Name
coagulation factor VIIprovided by RGD
Primary source
RGD:628678
See related
EnsemblRapid:ENSRNOG00000032737 AllianceGenome:RGD:628678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables endopeptidase activity and signaling receptor binding activity. Involved in several processes, including response to cholesterol; response to genistein; and response to thyroxine. Located in extracellular space and vesicle. Used to study asthma; diabetes mellitus; and type 2 diabetes mellitus. Biomarker of several diseases, including bilirubin metabolic disorder; familial hyperlipidemia; hypertension; hypothyroidism; and prothrombin deficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 424.4) See more
Orthologs
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Genomic context

Location:
16q12.5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83191896..83202775, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76489775..76500636, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81824610..81834923, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene PCI domain containing 2 Neighboring gene small ribosomal subunit protein eS19-like Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene coagulation factor X Neighboring gene uncharacterized LOC134482421 Neighboring gene MCF.2 cell line derived transforming sequence-like Neighboring gene ATPase phospholipid transporting 11A Neighboring gene uncharacterized LOC102548949

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables endopeptidase activity PubMed 
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
contributes_to serine-type endopeptidase activity  
enables signaling receptor binding PubMed 
Items 1 - 25 of 31
Process Evidence Code Pubs
involved_in animal organ regeneration PubMed 
involved_in blood coagulation  
involved_in blood coagulation  
acts_upstream_of_or_within blood coagulation  
involved_in blood coagulation  
involved_in circadian rhythm PubMed 
involved_in positive regulation of TOR signaling  
involved_in positive regulation of blood coagulation PubMed 
involved_in positive regulation of leukocyte chemotaxis  
involved_in positive regulation of leukocyte chemotaxis  
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway  
involved_in positive regulation of positive chemotaxis  
involved_in protein processing  
involved_in proteolysis  
involved_in response to 2,3,7,8-tetrachlorodibenzodioxine PubMed 
involved_in response to Thyroid stimulating hormone PubMed 
involved_in response to astaxanthin PubMed 
involved_in response to carbon dioxide PubMed 
involved_in response to cholesterol PubMed 
involved_in response to estradiol PubMed 
involved_in response to estrogen PubMed 
involved_in response to genistein PubMed 
involved_in response to growth hormone PubMed 
involved_in response to hormone PubMed 
involved_in response to hypoxia PubMed 
involved_in response to nutrient levels PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to thyroid hormone PubMed 
involved_in response to thyrotropin-releasing hormone PubMed 
involved_in response to thyroxine PubMed 
involved_in response to vitamin K PubMed 
Items 1 - 25 of 31
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
part_of serine-type peptidase complex  
located_in vesicle PubMed 

General protein information

Preferred Names
coagulation factor VII
Names
serum prothrombin conversion accelerator
NP_690059.1
XP_038950167.1
XP_038950168.1
XP_038950169.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152846.2NP_690059.1  coagulation factor VII precursor

    See identical proteins and their annotated locations for NP_690059.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q8K3U6
    UniProtKB/TrEMBL
    A6IWK3
    Related
    ENSRNOP00000038466.1, ENSRNOT00000037806.4
    Conserved Domains (3) summary
    smart00069
    Location:2585
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:87123
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:194430
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    83191896..83202775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094239.2XP_038950167.1  coagulation factor VII isoform X1

    UniProtKB/TrEMBL
    A6IWK3
    Conserved Domains (2) summary
    cd00054
    Location:71107
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:178414
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_039094241.2XP_038950169.1  coagulation factor VII isoform X3

    Conserved Domains (3) summary
    smart00069
    Location:2585
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:87123
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl21584
    Location:193218
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_039094240.2XP_038950168.1  coagulation factor VII isoform X2

    Conserved Domains (3) summary
    smart00069
    Location:2585
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:87123
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl21584
    Location:193263
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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