Aurka aurora kinase A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aurkaprovided by RGD
Official Full Name: aurora kinase Aprovided by RGD
Primary source: RGD:628895
See related: Ensembl:ENSRNOG00000004479 AllianceGenome:RGD:628895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stk6; ARK-1
Summary: Enables protein serine/threonine kinase activity. Involved in protein phosphorylation and response to estradiol. Located in centrosome and spindle. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 261.0), Liver (RPKM 143.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (181546742..181562890, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (161128309..161144524, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (170364177..170380278, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells.
Title: Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells.
AURKA ubiquitination influences mitochondrial dysfunction and suppresses the occurrence of OA via degradation of SOD2.
Title: Effects of AURKA-mediated degradation of SOD2 on mitochondrial dysfunction and cartilage homeostasis in osteoarthritis.
AURKA upregulation by Nkx6.1 results in phosphorylation and degradation of p53, thus removing a key inhibitory factor and permitting engagement of the beta-cell proliferation pathway.
Title: Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.
This study suggests that KRC-108 has potential for development as an anti-tumor agent, although further studies are needed.
Title: Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells.
These results demonstrate a direct positive role of estrogen in regulating Aurora-A expression through activation of the ERalpha-GATA-3 signaling cascade
Title: Estrogen-induced aurora kinase-A (AURKA) gene expression is activated by GATA-3 in estrogen receptor-positive breast cancer cells.
Data show that Aurora A interacts directly with the atypical protein kinase C binding domain of Par3 and phosphorylates it at serine 962.
Title: Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity.
Aurora-A overexpression is mediated by estrogen in female rats
Title: Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats.
Results suggest that the activities of Aurora kinases A and B are required for normal spindle assembly as well as for establishment and maintenance of proper microtubule-kinetochore attachments and spindle checkpoint signaling in male mammalian meiosis.
Title: Inhibition of Aurora kinases perturbs chromosome alignment and spindle checkpoint signaling in rat spermatocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130500 (e-PCR)
- UniSTS:213784

RH140220 (e-PCR)
- UniSTS:222299

RH138996 (e-PCR)
- UniSTS:221082

D19S915 (e-PCR)
- UniSTS:8418

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium disassembly	IEA Inferred from Electronic Annotation more info
involved_in cilium disassembly	ISO Inferred from Sequence Orthology more info
involved_in cilium disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in meiotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic centrosome separation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic centrosome separation	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oocyte maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in spindle assembly involved in female meiosis I	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spindle assembly involved in female meiosis I	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon hillock	IEA Inferred from Electronic Annotation more info
located_in axon hillock	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in germinal vesicle	IEA Inferred from Electronic Annotation more info
located_in germinal vesicle	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in meiotic spindle	IEA Inferred from Electronic Annotation more info
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in pronucleus	IEA Inferred from Electronic Annotation more info
located_in pronucleus	ISO Inferred from Sequence Orthology more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle pole centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole centrosome	IEA Inferred from Electronic Annotation more info
located_in spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aurora kinase A

Names: aurora 2; aurora-A; aurora-related kinase 1; aurora/IPL1-related kinase 1; ipl1- and aurora-related kinase 1; ratAurA; serine/threonine kinase 6; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase Ayk1; serine/threonine-protein kinase aurora-A

NP_695208.2

EC 2.7.11.1

XP_006235737.1

EC 2.7.11.1

XP_006235738.1

EC 2.7.11.1

XP_038960322.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429754.1 → NP_001416683.1 aurora kinase A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_153296.4 → NP_695208.2 aurora kinase A

See identical proteins and their annotated locations for NP_695208.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P59241

UniProtKB/TrEMBL

A0A8I5ZT82, A0A8I6APN1, F1LN52, Q3MHU2

Related

ENSRNOP00000084621.1, ENSRNOT00000097745.1

Conserved Domains (1) summary

cd14116
Location:120 → 376

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

181546742..181562890 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235675.5 → XP_006235737.1 aurora kinase A isoform X1

UniProtKB/Swiss-Prot

P59241

UniProtKB/TrEMBL

A0A8I5ZT82, A0A8I6APN1, F1LN52, Q3MHU2

Related

ENSRNOP00000081987.1

Conserved Domains (1) summary

cd14116
Location:120 → 376

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
XM_006235676.5 → XP_006235738.1 aurora kinase A isoform X1

UniProtKB/Swiss-Prot

P59241

UniProtKB/TrEMBL

A0A8I5ZT82, A0A8I6APN1, F1LN52, Q3MHU2

Related

ENSRNOP00000095702.1

Conserved Domains (1) summary

cd14116
Location:120 → 376

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
XM_039104394.2 → XP_038960322.1 aurora kinase A isoform X2

Conserved Domains (2) summary

PHA03247
Location:15 → 97

PHA03247; large tegument protein UL36; Provisional

cl21453
Location:120 → 182

PKc_like; Protein Kinases, catalytic domain