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ARL5A ADP ribosylation factor like GTPase 5A [ Homo sapiens (human) ]

Gene ID: 26225, updated on 5-Mar-2024

Summary

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Official Symbol
ARL5Aprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 5Aprovided by HGNC
Primary source
HGNC:HGNC:696
See related
Ensembl:ENSG00000162980 MIM:608960; AllianceGenome:HGNC:696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL5; ARFLP5
Summary
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 27.2), heart (RPKM 19.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (151798797..151828421, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (152250228..152279855, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (152655311..152684935, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:152266026-152266724 Neighboring gene replication timing regulatory factor 1 Neighboring gene uncharacterized LOC124906081 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:152410007-152411206 Neighboring gene nebulin Neighboring gene Sharpr-MPRA regulatory region 15124 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:152560612-152561164 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12007 Neighboring gene NEB-ARL5A intergenic CAGE-defined B cell enhancer Neighboring gene Sharpr-MPRA regulatory region 4301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16639 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16640 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:152731461-152732134 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:152770214-152770417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:152771361-152771862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:152835433-152835977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:152857391-152857891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16642 Neighboring gene NANOG hESC enhancer GRCh37_chr2:152890844-152891419 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:152906636-152907257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:152910243-152910744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12010 Neighboring gene ribosomal protein L30 pseudogene 2 Neighboring gene signal transducing adaptor molecule 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5. Shi M, et al. Nat Commun, 2018 Nov 26. PMID 30478271, Free PMC Article
  2. 2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins. Wang ZX, et al. Biochem Biophys Res Commun, 2005 Jul 8. PMID 15896705
  3. microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma. Wang Q, et al. Clin Cancer Res, 2014 Mar 1. PMID 24327274
  4. ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network. Ishida M, et al. J Cell Biol, 2019 Nov 4. PMID 31575603, Free PMC Article
  5. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. He H, et al. Gene Expr, 2002. PMID 12450215, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ARFRP1 functions upstream of two other ARL GTPases, ARL1 and ARL5, which in turn recruit golgins and GARP, respectively, to the trans-Golgi network (TGN).
    Title: ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.
  2. Arl5, an ARF-like family small GTPase, interacts with Ragulator in an amino acid-regulated manner and both Arl5 and its effector, the Golgi-associated retrograde protein complex (GARP), are required for the AA-stimulated trafficking.
    Title: Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5.
  3. microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma.
    Title: microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma.
  4. crystal structure
    Title: 2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins.
  5. developmentally regulated ARL5, with its distinctive nuclear/nucleolar localization and interaction with HP1alpha, may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development
    Title: A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies ARL5A, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 5A
Names
ADP-ribosylation factor-like 5
ADP-ribosylation factor-like 5A
ADP-ribosylation factor-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037174.2 → NP_001032251.1  ADP-ribosylation factor-like protein 5A isoform 2

    See identical proteins and their annotated locations for NP_001032251.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks alternate segments in the 5' UTR and coding region compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC097448
    Consensus CDS
    CCDS46425.1
    UniProtKB/TrEMBL
    B4DQS7
    Conserved Domains (1) summary
    cl38936
    Location:1 → 138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_012097.4 → NP_036229.1  ADP-ribosylation factor-like protein 5A isoform 1

    See identical proteins and their annotated locations for NP_036229.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC097448
    Consensus CDS
    CCDS2195.1
    UniProtKB/Swiss-Prot
    Q580I5, Q9Y689
    Related
    ENSP00000295087.8, ENST00000295087.13
    Conserved Domains (1) summary
    cd04153
    Location:3 → 175
    Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

  3. NM_177985.3 → NP_817114.2  ADP-ribosylation factor-like protein 5A isoform 2

    See identical proteins and their annotated locations for NP_817114.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR and coding region compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC097448, BX461356, CX867116
    Consensus CDS
    CCDS46425.1
    UniProtKB/TrEMBL
    B4DQS7
    Related
    ENSP00000415950.1, ENST00000428992.2
    Conserved Domains (1) summary
    cl38936
    Location:1 → 138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    151798797..151828421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    152250228..152279855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y689.1 GenPept UniProtKB/Swiss-Prot:Q9Y689

Gene LinkOut

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