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Zfp146 zinc finger protein 146 [ Mus musculus (house mouse) ]

Gene ID: 26465, updated on 30-Apr-2024

Summary

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Official Symbol
Zfp146provided by MGI
Official Full Name
zinc finger protein 146provided by MGI
Primary source
MGI:MGI:1347092
See related
Ensembl:ENSMUSG00000037029 AllianceGenome:MGI:1347092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OZF; Znf146
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleolus. Is expressed in branchial arch; eye; genitourinary system; and limb. Orthologous to human ZNF146 (zinc finger protein 146). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 33.5), CNS E14 (RPKM 24.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp146 in Genome Data Viewer
Location:
7 B1; 7 17.29 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29859912..29869225, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30160487..30169775, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 382 Neighboring gene STARR-seq mESC enhancer starr_18508 Neighboring gene zinc finger protein 334 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18509 Neighboring gene predicted gene 5113 Neighboring gene STARR-positive B cell enhancer ABC_E4914 Neighboring gene predicted gene, 53356 Neighboring gene cytochrome c oxidase subunit 7A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted expression of the only zinc finger gene in transgenic mice is associated with impaired mammary development. Besnar N, et al. Transgenic Res, 2002 Oct. PMID 12437081
  2. Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene. Blottière L, et al. Cytogenet Cell Genet, 1999. PMID 10449921
  3. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. Debrus S, et al. Mol Cell Biol, 2005 Oct. PMID 16166646, Free PMC Article
  4. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
  5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein OZF
Names
only zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357557.1 → NP_001344486.1  zinc finger protein OZF

    Status: VALIDATED

    Source sequence(s)
    AC164703
    Consensus CDS
    CCDS21079.1
    UniProtKB/Swiss-Prot
    A0JNX3, Q8BQN6, Q9Z0Q5
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

  2. NM_011980.4 → NP_036110.1  zinc finger protein OZF

    See identical proteins and their annotated locations for NP_036110.1

    Status: VALIDATED

    Source sequence(s)
    AC164703
    Consensus CDS
    CCDS21079.1
    UniProtKB/Swiss-Prot
    A0JNX3, Q8BQN6, Q9Z0Q5
    Related
    ENSMUSP00000058588.8, ENSMUST00000062181.9
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29859912..29869225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540008.4 → XP_006540071.1  zinc finger protein OZF isoform X1

    See identical proteins and their annotated locations for XP_006540071.1

    UniProtKB/Swiss-Prot
    A0JNX3, Q8BQN6, Q9Z0Q5
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036153136.1 → XP_036009029.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    A0JNX3, Q8BQN6, Q9Z0Q5
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036153137.1 → XP_036009030.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    A0JNX3, Q8BQN6, Q9Z0Q5
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain

  4. XM_030242608.2 → XP_030098468.1  zinc finger protein OZF isoform X1

    UniProtKB/Swiss-Prot
    A0JNX3, Q8BQN6, Q9Z0Q5
    Conserved Domains (3) summary
    COG5048
    Location:1 → 260
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 279
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQN6.2 GenPept UniProtKB/Swiss-Prot:Q8BQN6

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