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Slc27a3 solute carrier family 27 (fatty acid transporter), member 3 [ Mus musculus (house mouse) ]

Gene ID: 26568, updated on 5-Mar-2024

Summary

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Official Symbol
Slc27a3provided by MGI
Official Full Name
solute carrier family 27 (fatty acid transporter), member 3provided by MGI
Primary source
MGI:MGI:1347358
See related
Ensembl:ENSMUSG00000027932 AllianceGenome:MGI:1347358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FATP3; Acsvl3; FATP-3; Vlcs-3
Summary
Enables fatty-acyl-CoA synthase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to act upstream of or within acyl-CoA metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human SLC27A3 (solute carrier family 27 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 148.3), ovary adult (RPKM 32.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 39.22 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90292540..90298693, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90385230..90390835, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 4B Neighboring gene microRNA 7012 Neighboring gene STARR-positive B cell enhancer ABC_E28 Neighboring gene GATA zinc finger domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_08281 Neighboring gene STARR-positive B cell enhancer ABC_E9009 Neighboring gene STARR-seq mESC enhancer starr_08284 Neighboring gene integrator complex subunit 3 Neighboring gene STARR-seq mESC enhancer starr_08286 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90237240-90237349 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90237716-90237903 Neighboring gene STARR-seq mESC enhancer starr_08287 Neighboring gene STARR-seq mESC enhancer starr_08288 Neighboring gene STARR-positive B cell enhancer ABC_E6072 Neighboring gene STARR-positive B cell enhancer ABC_E56 Neighboring gene natriuretic peptide receptor 1 Neighboring gene nuclear encoded tRNA methionine 11 (anticodon CAT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. Pei Z, et al. J Biol Chem, 2004 Dec 24. PMID 15469937
  2. mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle. Han LQ, et al. Genet Mol Res, 2010 Jun 29. PMID 20603810
  3. Differential expression of fatty acid transport proteins in epidermis and skin appendages. Schmuth M, et al. J Invest Dermatol, 2005 Dec. PMID 16354187
  4. X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. Jia Z, et al. Mol Genet Metab, 2004 Sep-Oct. PMID 15464426
  5. The expression and function of fatty acid transport protein-2 and -4 in the murine placenta. Mishima T, et al. PLoS One, 2011. PMID 22028793, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle
    Title: mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle.
  2. studies cast doubt on the designation of very long-chain acyl-CoA synthetase 3 (ACSVL3) as a fatty acid transport protein
    Title: Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty-acyl-CoA synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables very long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acyl-CoA metabolic process IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
NOT acts_upstream_of_or_within fatty acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
long-chain fatty acid transport protein 3
Names
arachidonate--CoA ligase
long-chain-fatty-acid--CoA ligase
mFLJ00207 protein
solute carrier family 27 member 3
very long-chain acyl-CoA synthetase homolog 3
NP_001303617.1
NP_036118.2
XP_011238431.1
XP_011238432.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316688.2 → NP_001303617.1  long-chain fatty acid transport protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC145082
    UniProtKB/TrEMBL
    F7CPA3
    Related
    ENSMUSP00000122599.2, ENSMUST00000132041.2
    Conserved Domains (1) summary
    cl17068
    Location:64 → 528
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_011988.4 → NP_036118.2  long-chain fatty acid transport protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036118.2

    Status: VALIDATED

    Source sequence(s)
    AC145082
    Consensus CDS
    CCDS17527.1
    UniProtKB/Swiss-Prot
    O88561, Q6PAU1, Q8BK70
    UniProtKB/TrEMBL
    B2RUG3, G3X8Y7
    Related
    ENSMUSP00000029541.6, ENSMUST00000029541.12
    Conserved Domains (2) summary
    PRK08279
    Location:62 → 666
    PRK08279; long-chain-acyl-CoA synthetase; Validated
    cl17068
    Location:88 → 657
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90292540..90298693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240129.4 → XP_011238431.1  long-chain fatty acid transport protein 3 isoform X1

    UniProtKB/Swiss-Prot
    O88561, Q6PAU1, Q8BK70
    UniProtKB/TrEMBL
    B2RUG3
    Conserved Domains (1) summary
    cl17068
    Location:87 → 609
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_011240130.3 → XP_011238432.1  long-chain fatty acid transport protein 3 isoform X2

    Conserved Domains (1) summary
    cl17068
    Location:37 → 480
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88561.2 GenPept UniProtKB/Swiss-Prot:O88561

Gene LinkOut

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