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DUX3 double homeobox 3 [ Homo sapiens (human) ]

Gene ID: 26582, updated on 23-Nov-2023

Summary

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Official Symbol
DUX3provided by HGNC
Official Full Name
double homeobox 3provided by HGNC
Primary source
HGNC:HGNC:3081
See related
MIM:611443
Gene type
protein coding
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX3, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]
Annotation information
not in current annotation release
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Bibliography

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Related articles in PubMed

  1. Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. Beckers M, et al. Gene, 2001 Feb 7. PMID 11245978
  2. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Beilina A, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24510904, Free PMC Article
  3. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative double homeobox protein 3

NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012148.2: Suppressed sequence

    Description
    NM_012148.2: This RefSeq was removed because it does not align to the current assembly.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PT4.1 GenPept UniProtKB/Swiss-Prot:Q96PT4

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous