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Tmprss5 transmembrane serine protease 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266681, updated on 13-Apr-2024

Summary

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Official Symbol
Tmprss5provided by RGD
Official Full Name
transmembrane serine protease 5provided by RGD
Primary source
RGD:628625
See related
Ensembl:ENSRNOG00000008058 AllianceGenome:RGD:628625
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Amp
Summary
Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in neuronal cell body. Predicted to be active in plasma membrane. Orthologous to human TMPRSS5 (transmembrane serine protease 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 34.8), Muscle (RPKM 16.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmprss5 in Genome Data Viewer
Location:
8q23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (58338455..58357886)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (49437321..49461395)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53411259..53430744)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene claudin 25 Neighboring gene zw10 kinetochore protein Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134480049 Neighboring gene uncharacterized LOC134480047

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of two alternate splice variants of a novel serine protease expressed in steroidogenic tissues. Omer S, et al. Endocr Res, 2002 Nov. PMID 12530635
  2. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Guipponi M, et al. Hum Mutat, 2008 Jan. PMID 17918732
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AmP-Long has no effect on steroidogenesis nor cleaves StAR as was shown by western blot analysis using StAR antibody.
    Title: Identification of two alternate splice variants of a novel serine protease expressed in steroidogenic tissues.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protease serine 5
Names
adrenal mitochondrial protease
transmembrane protease, serine 5 (spinesin)
NP_695223.2
XP_038936856.1
XP_038936857.1
XP_063121060.1
XP_063121061.1
XP_063121062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153311.2 → NP_695223.2  transmembrane protease serine 5

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J4B2, Q8CJ17
    Related
    ENSRNOP00000011107.7, ENSRNOT00000011107.8
    Conserved Domains (2) summary
    cd00190
    Location:208 → 441
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:106 → 203
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    58338455..58357886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264990.1 → XP_063121060.1  transmembrane protease serine 5 isoform X1

  2. XM_063264992.1 → XP_063121062.1  transmembrane protease serine 5 isoform X4

  3. XM_063264991.1 → XP_063121061.1  transmembrane protease serine 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A2F3

  4. XM_039080928.2 → XP_038936856.1  transmembrane protease serine 5 isoform X3

    UniProtKB/TrEMBL
    A6J4B4
    Conserved Domains (2) summary
    cd00190
    Location:150 → 383
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:48 → 145
    SRCR_2; Scavenger receptor cysteine-rich domain

  5. XM_039080929.2 → XP_038936857.1  transmembrane protease serine 5 isoform X5

    UniProtKB/TrEMBL
    A6J4B4
    Conserved Domains (2) summary
    cd00190
    Location:74 → 307
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:3 → 69
    SRCR_2; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version

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