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Dhrs4 dehydrogenase/reductase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266686, updated on 2-May-2024

Summary

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Official Symbol
Dhrs4provided by RGD
Official Full Name
dehydrogenase/reductase 4provided by RGD
Primary source
RGD:708482
See related
Ensembl:ENSRNOG00000018239 AllianceGenome:RGD:708482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PSCD
Summary
Predicted to enable several functions, including identical protein binding activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Predicted to be involved in several processes, including positive regulation of reactive oxygen species metabolic process; retinal metabolic process; and steroid metabolic process. Located in peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 361.9), Liver (RPKM 304.4) and 9 other tissues See more
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Genomic context

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Location:
15p13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32924482..32948103)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28966544..28978135)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34155043..34167073)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482121 Neighboring gene uncharacterized LOC102551831 Neighboring gene ribosomal protein S17, pseudogene 8 Neighboring gene uncharacterized LOC102552093 Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel isoform of DHRS4 protein with a nuclear localization signal. Su Z, et al. Gene, 2012 Feb 25. PMID 22227495
  2. Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity. Matsunaga T, et al. Arch Biochem Biophys, 2008 Sep 15. PMID 18571493
  3. Molecular basis for peroxisomal localization of tetrameric carbonyl reductase. Tanaka N, et al. Structure, 2008 Mar. PMID 18334214
  4. Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate. Lei Z, et al. Biochemistry, 2003 Apr 15. PMID 12680773
  5. Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). Endo S, et al. Arch Biochem Biophys, 2009 Jan 15. PMID 19056333

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-keto sterol reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonyl reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in alcohol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular ketone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular ketone metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinal metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinal metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 4
Names
CR
DCR-AKL
NADP-retinol dehydrogenase
NADPH-dependent carbonyl reductase
NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
NADPH-dependent retinol dehydrogenase/reductase
NDRD
PHCR
carbonyl reductase
dehydrogenase/reductase (SDR family) member 4
peroxisomal short-chain alcohol dehydrogenase
short chain dehydrogenase/reductase family 25C member 2
NP_695227.2
XP_038948968.1
XP_063130103.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153315.2 → NP_695227.2  dehydrogenase/reductase SDR family member 4

    See identical proteins and their annotated locations for NP_695227.2

    Status: VALIDATED

    Source sequence(s)
    BC070961
    UniProtKB/Swiss-Prot
    Q6IRD4, Q8VID1
    UniProtKB/TrEMBL
    A0A8I5ZUW8
    Related
    ENSRNOP00000024782.3, ENSRNOT00000024782.5
    Conserved Domains (1) summary
    cd08936
    Location:24 → 279
    CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    32924482..32948103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274033.1 → XP_063130103.1  dehydrogenase/reductase SDR family member 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6IRD4, Q8VID1

  2. XM_039093040.2 → XP_038948968.1  dehydrogenase/reductase SDR family member 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUW8
    Conserved Domains (1) summary
    cl21454
    Location:24 → 225
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VID1.2 GenPept UniProtKB/Swiss-Prot:Q8VID1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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