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Klhl12 kelch-like family member 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266772, updated on 2-May-2024

Summary

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Official Symbol
Klhl12provided by RGD
Official Full Name
kelch-like family member 12provided by RGD
Primary source
RGD:628717
See related
Ensembl:ENSRNOG00000004193 AllianceGenome:RGD:628717
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C3ip1
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including COPII vesicle coating; mesenchymal cell differentiation; and protein monoubiquitination. Predicted to be located in centriolar satellite and intracellular membrane-bounded organelle. Predicted to be part of COPII vesicle coat and Cul3-RING ubiquitin ligase complex. Predicted to be active in COPII-coated ER to Golgi transport vesicle. Orthologous to human KLHL12 (kelch like family member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 102.3), Adrenal (RPKM 93.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl12 in Genome Data Viewer
Location:
13q13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48451920..48485638)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45899913..45933648)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51280933..51314753)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene adiponectin receptor 1 Neighboring gene long non-coding RNA 134 Neighboring gene NADH:ubiquinone oxidoreductase subunit V3, pseudogene 1 Neighboring gene uncharacterized LOC134481560 Neighboring gene RAB interacting factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A regulator of secretory vesicle size, Kelch-like protein 12, facilitates the secretion of apolipoprotein B100 and very-low-density lipoproteins--brief report. Butkinaree C, et al. Arterioscler Thromb Vasc Biol, 2014 Feb. PMID 24334870, Free PMC Article
  2. Ubiquitin-dependent regulation of COPII coat size and function. Jin L, et al. Nature, 2012 Feb 22. PMID 22358839, Free PMC Article
  3. Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein. Funato Y, et al. Curr Biol, 2010 Nov 9. PMID 20970343
  4. Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor. McGourty CA, et al. Cell, 2016 Oct 6. PMID 27716508
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KLHL12 plays a critical role in facilitating the endoplasmic reticulum exit and secretion of apoB100-VLDL particles, suggesting that KLHL12 modulation would influence plasma lipid levels.
    Title: A regulator of secretory vesicle size, Kelch-like protein 12, facilitates the secretion of apolipoprotein B100 and very-low-density lipoproteins--brief report.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93127

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII vesicle coating IEA
Inferred from Electronic Annotation
more info
  
involved_in COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
  
involved_in COPII vesicle coating ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural crest cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural crest formation IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest formation ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
  
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
  
part_of COPII vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in COPII-coated ER to Golgi transport vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in COPII-coated ER to Golgi transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Cul3-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 12
Names
CUL3-interacting protein 1
kelch-like 12
kelch-like protein C3IP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153730.2 → NP_714952.1  kelch-like protein 12

    See identical proteins and their annotated locations for NP_714952.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ133126
    UniProtKB/TrEMBL
    A6ICC3
    Conserved Domains (4) summary
    PHA03098
    Location:46 → 550
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:416 → 459
    Kelch; KELCH repeat [structural motif]
    cd18242
    Location:12 → 135
    BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
    cd18452
    Location:130 → 265
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    48451920..48485638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090401.2 → XP_038946329.1  kelch-like protein 12 isoform X1

    Conserved Domains (4) summary
    PHA03098
    Location:63 → 574
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:440 → 483
    Kelch; KELCH repeat [structural motif]
    cd18242
    Location:29 → 159
    BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
    cd18452
    Location:154 → 289
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  2. XM_039090402.2 → XP_038946330.1  kelch-like protein 12 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A1G7
    Related
    ENSRNOP00000086049.1
    Conserved Domains (4) summary
    PHA03098
    Location:63 → 567
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:433 → 476
    Kelch; KELCH repeat [structural motif]
    cd18242
    Location:29 → 152
    BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
    cd18452
    Location:147 → 282
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  3. XM_006249843.5 → XP_006249905.1  kelch-like protein 12 isoform X3

    See identical proteins and their annotated locations for XP_006249905.1

    UniProtKB/TrEMBL
    A0A140TA97
    Related
    ENSRNOP00000005832.7
    Conserved Domains (4) summary
    PHA03098
    Location:46 → 557
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423 → 466
    Kelch; KELCH repeat [structural motif]
    cd18242
    Location:12 → 142
    BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
    cd18452
    Location:137 → 272
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  4. XM_039090408.2 → XP_038946336.1  kelch-like protein 12 isoform X6

    Conserved Domains (4) summary
    PHA03098
    Location:83 → 443
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:309 → 352
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:29 → 82
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:82 → 158
    BACK; BACK (BTB and C-terminal Kelch) domain

  5. XM_039090404.2 → XP_038946332.1  kelch-like protein 12 isoform X3

    UniProtKB/TrEMBL
    A0A140TA97
    Conserved Domains (4) summary
    PHA03098
    Location:46 → 557
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423 → 466
    Kelch; KELCH repeat [structural motif]
    cd18242
    Location:12 → 142
    BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
    cd18452
    Location:137 → 272
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  6. XM_063272056.1 → XP_063128126.1  kelch-like protein 12 isoform X4

    UniProtKB/TrEMBL
    A6ICC3

  7. XM_006249845.3 → XP_006249907.1  kelch-like protein 12 isoform X4

    See identical proteins and their annotated locations for XP_006249907.1

    UniProtKB/TrEMBL
    A6ICC3
    Conserved Domains (4) summary
    PHA03098
    Location:46 → 550
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:416 → 459
    Kelch; KELCH repeat [structural motif]
    cd18242
    Location:12 → 135
    BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
    cd18452
    Location:130 → 265
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  8. XM_006249844.5 → XP_006249906.1  kelch-like protein 12 isoform X3

    See identical proteins and their annotated locations for XP_006249906.1

    UniProtKB/TrEMBL
    A0A140TA97
    Conserved Domains (4) summary
    PHA03098
    Location:46 → 557
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423 → 466
    Kelch; KELCH repeat [structural motif]
    cd18242
    Location:12 → 142
    BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
    cd18452
    Location:137 → 272
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  9. XM_008769540.4 → XP_008767762.1  kelch-like protein 12 isoform X5

    See identical proteins and their annotated locations for XP_008767762.1

    Conserved Domains (3) summary
    PHA03098
    Location:4 → 467
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18452
    Location:47 → 182
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  10. XM_039090405.2 → XP_038946333.1  kelch-like protein 12 isoform X5

    Conserved Domains (3) summary
    PHA03098
    Location:4 → 467
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18452
    Location:47 → 182
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  11. XM_039090406.2 → XP_038946334.1  kelch-like protein 12 isoform X5

    Conserved Domains (3) summary
    PHA03098
    Location:4 → 467
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18452
    Location:47 → 182
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  12. XM_039090407.2 → XP_038946335.1  kelch-like protein 12 isoform X5

    Conserved Domains (3) summary
    PHA03098
    Location:4 → 467
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18452
    Location:47 → 182
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2H4.2 GenPept UniProtKB/Swiss-Prot:Q8R2H4

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