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Rimbp2 RIMS binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266780, updated on 4-Apr-2024

Summary

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Official Symbol
Rimbp2provided by RGD
Official Full Name
RIMS binding protein 2provided by RGD
Primary source
RGD:708533
See related
Ensembl:ENSRNOG00000022893 AllianceGenome:RGD:708533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rbp2; RIM-BP2
Summary
Predicted to be involved in neuromuscular synaptic transmission. Predicted to be located in plasma membrane. Predicted to be active in presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 95.4), Brain (RPKM 54.2) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q13
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (33383646..33582259)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (27747615..27946256)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (31393229..31605567)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene syntaxin 2 Neighboring gene translation machinery-associated protein 7-like Neighboring gene uncharacterized LOC108352441 Neighboring gene piwi-like RNA-mediated gene silencing 1 Neighboring gene frizzled class receptor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation. Wu X, et al. Mol Cell, 2019 Mar 7. PMID 30661983
  2. RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Grauel MK, et al. Proc Natl Acad Sci U S A, 2016 Oct 11. PMID 27671655, Free PMC Article
  3. Structure and evolution of RIM-BP genes: identification of a novel family member. Mittelstaedt T, et al. Gene, 2007 Nov 15. PMID 17855024
  4. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. Wang Y, et al. J Biol Chem, 2000 Jun 30. PMID 10748113
  5. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in maintenance of presynaptic active zone structure IEA
Inferred from Electronic Annotation
more info
  
involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RIMS-binding protein 2
Names
RIM binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100488.4 → NP_001093958.1  RIMS-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I5ZR68, A0A8I6A6H1
    Related
    ENSRNOP00000080836.1, ENSRNOT00000100361.1
    Conserved Domains (6) summary
    cd12012
    Location:876 → 937
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:980 → 1040
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:192 → 252
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:508 → 594
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:414 → 478
    fn3; Fibronectin type III domain
    pfam15152
    Location:642 → 683
    Kisspeptin; Kisspeptin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    33383646..33582259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271095.1 → XP_063127165.1  RIMS-binding protein 2 isoform X2

  2. XM_063271096.1 → XP_063127166.1  RIMS-binding protein 2 isoform X3

  3. XM_039089127.2 → XP_038945055.1  RIMS-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4J8
    Related
    ENSRNOP00000059643.2
    Conserved Domains (7) summary
    cd12012
    Location:1106 → 1167
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:1210 → 1270
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185 → 245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:582 → 728
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:501 → 587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407 → 474
    fn3; Fibronectin type III domain
    pfam15905
    Location:4 → 88
    HMMR_N; Hyaluronan mediated motility receptor N-terminal

  4. XM_063271099.1 → XP_063127169.1  RIMS-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    A6J0T2

  5. XM_063271100.1 → XP_063127170.1  RIMS-binding protein 2 isoform X6

  6. XM_063271097.1 → XP_063127167.1  RIMS-binding protein 2 isoform X4

  7. XM_039089126.2 → XP_038945054.1  RIMS-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4J8
    Conserved Domains (7) summary
    cd12012
    Location:1106 → 1167
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:1210 → 1270
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185 → 245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:582 → 728
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:501 → 587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407 → 474
    fn3; Fibronectin type III domain
    pfam15905
    Location:4 → 88
    HMMR_N; Hyaluronan mediated motility receptor N-terminal

  8. XM_063271102.1 → XP_063127172.1  RIMS-binding protein 2 isoform X7

  9. XM_039089128.2 → XP_038945056.1  RIMS-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4J8
    Related
    ENSRNOP00000030915.5
    Conserved Domains (7) summary
    cd12012
    Location:1106 → 1167
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:1210 → 1270
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185 → 245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:582 → 728
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:501 → 587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407 → 474
    fn3; Fibronectin type III domain
    pfam15905
    Location:4 → 88
    HMMR_N; Hyaluronan mediated motility receptor N-terminal

  10. XM_039089129.2 → XP_038945057.1  RIMS-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4J8
    Conserved Domains (7) summary
    cd12012
    Location:1106 → 1167
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:1210 → 1270
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:185 → 245
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    PHA03321
    Location:582 → 728
    PHA03321; tegument protein VP11/12; Provisional
    cd00063
    Location:501 → 587
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:407 → 474
    fn3; Fibronectin type III domain
    pfam15905
    Location:4 → 88
    HMMR_N; Hyaluronan mediated motility receptor N-terminal

  11. XM_063271098.1 → XP_063127168.1  RIMS-binding protein 2 isoform X4

  12. XM_063271094.1 → XP_063127164.1  RIMS-binding protein 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIR1.2 GenPept UniProtKB/Swiss-Prot:Q9JIR1

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