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Akr7a3 aldo-keto reductase family 7 member A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 26760, updated on 13-Apr-2024

Summary

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Official Symbol
Akr7a3provided by RGD
Official Full Name
aldo-keto reductase family 7 member A3provided by RGD
Primary source
RGD:628635
See related
Ensembl:ENSRNOG00000017899 AllianceGenome:RGD:628635
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Afar; Akr7a1
Summary
Enables aldo-keto reductase (NADP) activity. Involved in aflatoxin catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to several human genes including AKR7A3 (aldo-keto reductase family 7 member A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1889.4) and Liver (RPKM 308.9) See more
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Genomic context

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See Akr7a3 in Genome Data Viewer
Location:
5q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156876721..156884599)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151590968..151601394)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157801120..157813756)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S21, pseudogene 9 Neighboring gene uncharacterized LOC134487025 Neighboring gene MRT4 homolog, ribosome maturation factor Neighboring gene ER membrane protein complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter. Ellis EM, et al. Carcinogenesis, 2003 Apr. PMID 12727802
  2. The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily. Kozma E, et al. J Biol Chem, 2002 May 3. PMID 11839745
  3. Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin. Hayes JD, et al. Cancer Res, 1993 Sep 1. PMID 8395332
  4. An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases. Ellis EM, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234296, Free PMC Article
  5. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3. Knight LP, et al. Carcinogenesis, 1999 Jul. PMID 10383892

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate that Akr7a3 mRNA and protein levels are consistently co-expressed along with Akr1b10, in both experimental rat liver carcinogenesis and some human hepatocellular carcinoma samples.
    Title: Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC.
  2. structure and chromosomal localization and idetification of antioxidant response elements in the gene promoter
    Title: Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter.
  3. A dimeric member of the aldo-keto reductase superfamily; structure resolved to 1.38A resolution (AKR7A1, aflatoxin dialdehyde reductase AKR7A1)
    Title: The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aflatoxin catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in aflatoxin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aflatoxin B1 aldehyde reductase member 3
Names
AFB1-AR
aflatoxin B1 aldehyde reductase member 1
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
rAFAR1
NP_037347.1
XP_038965273.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013215.2 → NP_037347.1  aflatoxin B1 aldehyde reductase member 3

    See identical proteins and their annotated locations for NP_037347.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P38918, Q5EBB7, Q68FZ3, Q9QX16
    UniProtKB/TrEMBL
    A0A8L2QCW7, A6ITL5
    Conserved Domains (1) summary
    cd19075
    Location:6 → 315
    AKR_AKR7A1-5; AKR7A family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    156876721..156884599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109345.2 → XP_038965273.1  aflatoxin B1 aldehyde reductase member 3 isoform X1

    Conserved Domains (1) summary
    cd19075
    Location:2 → 239
    AKR_AKR7A1-5; AKR7A family of aldo-keto reductase (AKR)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38918.2 GenPept UniProtKB/Swiss-Prot:P38918

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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