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Chst4 carbohydrate sulfotransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 26887, updated on 7-May-2024

Summary

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Official Symbol
Chst4provided by MGI
Official Full Name
carbohydrate sulfotransferase 4provided by MGI
Primary source
MGI:MGI:1349479
See related
Ensembl:ENSMUSG00000035930 AllianceGenome:MGI:1349479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GST-3; Gn6st-2; HEC-GlcNAc6ST
Summary
Enables N-acetylglucosamine 6-O-sulfotransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within leukocyte tethering or rolling and protein sulfation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including alimentary system; lymph node; nervous system; and urinary system. Orthologous to human CHST4 (carbohydrate sulfotransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 33.9), large intestine adult (RPKM 14.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 57.38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110755776..110766033, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110029075..110039401, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22664 Neighboring gene tyrosine aminotransferase Neighboring gene RIKEN cDNA 1700064F23 gene Neighboring gene STARR-seq mESC enhancer starr_22666 Neighboring gene RIKEN cDNA 8030455M16 gene Neighboring gene zinc finger protein 612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Hemmerich S, et al. Immunity, 2001 Aug. PMID 11520459
  2. Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses. Ohmichi Y, et al. J Exp Med, 2011 May 9. PMID 21518796, Free PMC Article
  3. N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury. Ito Z, et al. J Neurosci, 2010 Apr 28. PMID 20427653, Free PMC Article
  4. Conditional gene targeting in mouse high endothelial venules. Kawashima H, et al. J Immunol, 2009 May 1. PMID 19380794, Free PMC Article
  5. A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules. Uchimura K, et al. Nat Immunol, 2005 Nov. PMID 16227986

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GlcNAc6ST-2, whose expression is regulated by butyrate, is a major sulfotransferase in the biosynthesis of sulfomucins in the mouse colon, where they serve as a mucosal barrier against colonic inflammation
    Title: Sulfation of colonic mucins by N-acetylglucosamine 6-O-sulfotransferase-2 and its protective function in experimental colitis in mice.
  2. N-acetylglucosamine-6-O-sulfotransferases (GlcNAc6ST-1 and GlcNAc6ST-2) deficiency results in elimination of both peripheral node addressin and sialyl 6-sulfo Lewis X in high endothelial venules.
    Title: A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules.
  3. plays a critical role in lymphocyte trafficking during chronic inflammation
    Title: Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing.
  4. GST-3 is responsible for MECA-79 defined luminal ligands
    Title: Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylglucosamine 6-O-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein sulfation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 4
Names
L-selectin ligand sulfotransferase
LSST
N-acetylglucosamine 6-O-sulfotransferase 2
carbohydrate (chondroitin 6/keratan) sulfotransferase 4
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3
glcNAc6ST-2
high endothelial cell GlcNAC-6-sulphotransferase
high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
NP_001411745.1
NP_001411746.1
NP_036128.3
XP_006531108.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424816.1 → NP_001411745.1  carbohydrate sulfotransferase 4

    Status: VALIDATED

    Source sequence(s)
    AC124409
    UniProtKB/TrEMBL
    A0A0R4J1C9

  2. NM_001424817.1 → NP_001411746.1  carbohydrate sulfotransferase 4

    Status: VALIDATED

    Source sequence(s)
    AC124409
    UniProtKB/TrEMBL
    A0A0R4J1C9

  3. NM_011998.5 → NP_036128.3  carbohydrate sulfotransferase 4

    See identical proteins and their annotated locations for NP_036128.3

    Status: VALIDATED

    Source sequence(s)
    AC124409
    Consensus CDS
    CCDS22659.1
    UniProtKB/Swiss-Prot
    Q9R1I1, Q9WUE5
    UniProtKB/TrEMBL
    A0A0R4J1C9
    Related
    ENSMUSP00000104845.3, ENSMUST00000109222.4
    Conserved Domains (1) summary
    cl21551
    Location:44 → 297
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110755776..110766033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531045.4 → XP_006531108.1  carbohydrate sulfotransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006531108.1

    UniProtKB/Swiss-Prot
    Q9R1I1, Q9WUE5
    UniProtKB/TrEMBL
    A0A0R4J1C9
    Conserved Domains (1) summary
    cl21551
    Location:44 → 297
    Sulfotransfer_3; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1I1.1 GenPept UniProtKB/Swiss-Prot:Q9R1I1

Gene LinkOut

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