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Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 [ Mus musculus (house mouse) ]

Gene ID: 27400, updated on 11-Apr-2024

Summary

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Official Symbol
Hsd17b6provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 6provided by MGI
Primary source
MGI:MGI:1351670
See related
Ensembl:ENSMUSG00000025396 AllianceGenome:MGI:1351670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rdh8; Hsd17b9; 17betaHSD9
Summary
Enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in brexanolone catabolic process. Predicted to act upstream of or within steroid metabolic process. Predicted to be located in endoplasmic reticulum; endosome; and membrane. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 99.6), duodenum adult (RPKM 16.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Hsd17b6 in Genome Data Viewer
Location:
10 D3; 10 76.39 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127826800..127843517, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127990931..128007648, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28251 Neighboring gene predicted gene, 23996 Neighboring gene STARR-seq mESC enhancer starr_28252 Neighboring gene ring finger protein 181 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8376 Neighboring gene STARR-positive B cell enhancer ABC_E9812 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene DNA primase, p49 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17beta/3alpha-hydroxysteroid/retinoid short chain dehydrogenase/reductase. Su J, et al. Endocrinology, 1999 Nov. PMID 10537158
  2. HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation. Wei F, et al. Metabolism, 2023 Aug. PMID 37330135
  3. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Yi J, et al. Hepatology, 2016 Nov. PMID 27531557, Free PMC Article
  4. The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. Labialle S, et al. EMBO J, 2014 Oct 1. PMID 25124681, Free PMC Article
  5. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.
    Title: HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables androstan-3-alpha,17-beta-diol dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables testosterone dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables testosterone dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in brexanolone catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
17-beta-hydroxysteroid dehydrogenase type 6
Names
17-beta-HSD 6
17-beta-HSD6
17-beta-HSD9
3-alpha->beta-HSE
3-alpha->beta-hydroxysteroid epimerase
hydroxysteroid (17-beta) dehydrogenase 9
oxidative 3-alpha hydroxysteroid dehydrogenase
NP_001346306.1
NP_038814.1
XP_011241766.1
XP_011241767.1
XP_011241769.1
XP_011241770.1
XP_030100965.1
XP_030100966.1
XP_030100967.1
XP_030100968.1
XP_030100969.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359377.1 → NP_001346306.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC131120, AK008212
    Consensus CDS
    CCDS24257.1
    UniProtKB/Swiss-Prot
    Q9R092
    Related
    ENSMUSP00000151661.2, ENSMUST00000219183.2
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001428920.1 → NP_001415849.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC131120

  3. NM_001428921.1 → NP_001415850.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC131120

  4. NM_001428922.1 → NP_001415851.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC131120

  5. NM_001428923.1 → NP_001415852.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC131120

  6. NM_001428924.1 → NP_001415853.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform b.
    Source sequence(s)
    AC131120

  7. NM_001428925.1 → NP_001415854.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC131120

  8. NM_013786.4 → NP_038814.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

    See identical proteins and their annotated locations for NP_038814.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC131120
    Consensus CDS
    CCDS24257.1
    UniProtKB/Swiss-Prot
    Q9R092
    Related
    ENSMUSP00000151556.2, ENSMUST00000219447.2
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_190539.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131120

  2. NR_190540.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131120

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127826800..127843517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243465.3 → XP_011241767.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_011243464.3 → XP_011241766.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_030245105.1 → XP_030100965.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_030245108.1 → XP_030100968.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. XM_030245106.1 → XP_030100966.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  6. XM_030245107.1 → XP_030100967.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  7. XM_011243467.3 → XP_011241769.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30 → 306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  8. XM_030245109.1 → XP_030100969.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:30 → 262
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  9. XM_011243468.3 → XP_011241770.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:30 → 262
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R092.1 GenPept UniProtKB/Swiss-Prot:Q9R092

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