U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KCNMA1 potassium calcium-activated channel subfamily M alpha 1 [ Bos taurus (cattle) ]

Gene ID: 282573, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
KCNMA1provided by VGNC
Official Full Name
potassium calcium-activated channel subfamily M alpha 1provided by VGNC
Primary source
VGNC:VGNC:30479
See related
Ensembl:ENSBTAG00000013300
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 28
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (32610164..33387461, complement)

Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene leucine rich melanocyte differentiation associated Neighboring gene uncharacterized LOC132344158 Neighboring gene uncharacterized LOC107131390 Neighboring gene uncharacterized LOC132344143 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene microRNA mir-2285ba-1 Neighboring gene microRNA mir-2285cl Neighboring gene discs large MAGUK scaffold protein 5 Neighboring gene RNA polymerase III subunit A

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A molecular switch for specific stimulation of the BKCa channel by cGMP and cAMP kinase. Zhou XB, et al. J Biol Chem, 2001 Nov 16. PMID 11514553
  2. CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels. Liu J, et al. Nat Neurosci, 2006 Jan. PMID 16341213, Free PMC Article
  3. Syntaxin 1A co-associates with native rat brain and cloned large conductance, calcium-activated potassium channels in situ. Ling S, et al. J Physiol, 2003 Nov 15. PMID 12949219, Free PMC Article
  4. Bovine and mouse SLO3 K+ channels: evolutionary divergence points to an RCK1 region of critical function. Santi CM, et al. J Biol Chem, 2009 Aug 7. PMID 19473978, Free PMC Article
  5. An evolutionarily conserved binding site for serine proteinase inhibitors in large conductance calcium-activated potassium channels. Moss GW, et al. Biochemistry, 1996 Dec 17. PMID 8973172

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of SLO3 K+ channels shows evolutionary divergence for an RCK1 region of critical function
    Title: Bovine and mouse SLO3 K+ channels: evolutionary divergence points to an RCK1 region of critical function.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables large conductance calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
calcium-activated potassium channel subunit alpha-1
Names
BK channel
BKCA alpha
KCa1.1
bSlo
calcium-activated potassium channel, subfamily M subunit alpha-1
k(VCA)alpha
maxi K channel
maxiK
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
slo homolog
slo-alpha
slo1
slowpoke homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174680.2 → NP_777105.1  calcium-activated potassium channel subunit alpha-1

    See identical proteins and their annotated locations for NP_777105.1

    Status: PROVISIONAL

    Source sequence(s)
    AY033472
    UniProtKB/Swiss-Prot
    Q28204, Q95J89, Q95J90, Q95J91
    UniProtKB/TrEMBL
    A0A3Q1MJG6
    Related
    ENSBTAP00000085648.1, ENSBTAT00000094706.1
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 384
    Ion_trans; Ion transport protein
    pfam03493
    Location:526 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:434 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    32610164..33387461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986560.2 → XP_024842328.1  calcium-activated potassium channel subunit alpha-1 isoform X8

    UniProtKB/TrEMBL
    A0A3Q1MJG6, F1MST8
    Related
    ENSBTAP00000017697.7, ENSBTAT00000017697.7
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 384
    Ion_trans; Ion transport protein
    pfam03493
    Location:526 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:434 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_024986559.2 → XP_024842327.1  calcium-activated potassium channel subunit alpha-1 isoform X7

    UniProtKB/TrEMBL
    A0A3Q1MJG6
    Related
    ENSBTAP00000047743.3, ENSBTAT00000054334.4
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 384
    Ion_trans; Ion transport protein
    pfam03493
    Location:526 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:434 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_024986567.2 → XP_024842335.1  calcium-activated potassium channel subunit alpha-1 isoform X12

    UniProtKB/TrEMBL
    F1MSP6
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 384
    Ion_trans; Ion transport protein
    pfam03493
    Location:533 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:398 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_059882448.1 → XP_059738431.1  calcium-activated potassium channel subunit alpha-1 isoform X6

  5. XM_059882447.1 → XP_059738430.1  calcium-activated potassium channel subunit alpha-1 isoform X5

  6. XM_024986564.2 → XP_024842332.1  calcium-activated potassium channel subunit alpha-1 isoform X10

    UniProtKB/TrEMBL
    F1MSP6
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 384
    Ion_trans; Ion transport protein
    pfam03493
    Location:533 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:398 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  7. XM_024986558.2 → XP_024842326.1  calcium-activated potassium channel subunit alpha-1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MJG6
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 384
    Ion_trans; Ion transport protein
    pfam03493
    Location:533 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:398 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  8. XM_024986557.2 → XP_024842325.1  calcium-activated potassium channel subunit alpha-1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MJG6
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 384
    Ion_trans; Ion transport protein
    pfam03493
    Location:533 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:398 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  9. XM_059882446.1 → XP_059738429.1  calcium-activated potassium channel subunit alpha-1 isoform X2

  10. XM_059882445.1 → XP_059738428.1  calcium-activated potassium channel subunit alpha-1 isoform X1

  11. XM_024986563.2 → XP_024842331.1  calcium-activated potassium channel subunit alpha-1 isoform X11

    UniProtKB/TrEMBL
    A0A3Q1MJG6
    Related
    ENSBTAP00000071482.2, ENSBTAT00000076957.2
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 384
    Ion_trans; Ion transport protein
    pfam03493
    Location:533 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:398 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  12. XM_059882450.1 → XP_059738433.1  calcium-activated potassium channel subunit alpha-1 isoform X13

  13. XM_024986573.2 → XP_024842341.1  calcium-activated potassium channel subunit alpha-1 isoform X14

    UniProtKB/TrEMBL
    A0A3Q1MJG6
    Related
    ENSBTAP00000103211.1, ENSBTAT00000091654.1
    Conserved Domains (3) summary
    pfam00520
    Location:167 → 375
    Ion_trans; Ion transport protein
    pfam03493
    Location:526 → 621
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:434 → 511
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  14. XM_024986562.2 → XP_024842330.1  calcium-activated potassium channel subunit alpha-1 isoform X9

  15. XM_059882449.1 → XP_059738432.1  calcium-activated potassium channel subunit alpha-1 isoform X9

RNA

  1. XR_009493216.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28204.2 GenPept UniProtKB/Swiss-Prot:Q28204

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.