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Elavl3 ELAV like RNA binding protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 282824, updated on 4-Apr-2024

Summary

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Official Symbol
Elavl3provided by RGD
Official Full Name
ELAV like RNA binding protein 3provided by RGD
Primary source
RGD:628892
See related
Ensembl:ENSRNOG00000013752 AllianceGenome:RGD:628892
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Huc
Summary
Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be part of ribonucleoprotein complex. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 155.0) See more
Orthologs
human mouse all
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Genomic context

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See Elavl3 in Genome Data Viewer
Location:
8q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28823120..28859395, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20547108..20583369, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23029980..23063477, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480147 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene PRKCSH beta subunit of glucosidase II Neighboring gene zinc finger protein 653 Neighboring gene uncharacterized LOC120094091 Neighboring gene ECSIT signaling integrator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C. Inoue M, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734193, Free PMC Article
  2. Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC. Abe R, et al. Nucleic Acids Res, 1996 Dec 15. PMID 9016658, Free PMC Article
  3. Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons. Fornaro M, et al. Ann Anat, 2007. PMID 17534028
  4. RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay. King PH. Nucleic Acids Res, 2000 Apr 1. PMID 10710437, Free PMC Article
  5. HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens. Bitel CL, et al. Mol Vis, 2010 Nov 4. PMID 21139978, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Part of a family of RNa-binding proteins found in sensory neurons.
    Title: Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons.
  2. The predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate lenses, was shown.
    Title: HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ELAV-like protein 3
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
ELAV like neuron-specific RNA binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172324.3 → NP_758827.1  ELAV-like protein 3

    See identical proteins and their annotated locations for NP_758827.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AIP7, Q76IJ9
    Related
    ENSRNOP00000092942.1, ENSRNOT00000113602.1
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 366
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28823120..28859395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242616.5 → XP_006242678.3  ELAV-like protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AIP7
    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 359
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. XM_017595490.3 → XP_017450979.2  ELAV-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIP7
    Conserved Domains (1) summary
    TIGR01661
    Location:35 → 365
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. XM_063264993.1 → XP_063121063.1  ELAV-like protein 3 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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