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ZNF621 zinc finger protein 621 [ Homo sapiens (human) ]

Gene ID: 285268, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF621provided by HGNC
Official Full Name
zinc finger protein 621provided by HGNC
Primary source
HGNC:HGNC:24787
See related
Ensembl:ENSG00000172888 AllianceGenome:HGNC:24787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 3.3), brain (RPKM 3.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
3p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (40523106..40539782)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (40538147..40554832)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (40566451..40581273)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U5B small nuclear 2, pseudogene Neighboring gene zinc finger protein 620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19719 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:40566421-40567233 Neighboring gene uncharacterized LOC124909368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:40625449-40625949 Neighboring gene ribosomal protein L5 pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma Cells Through the ceRNA Network. Li J, et al. Cell Mol Biol (Noisy-le-grand), 2022 Apr 30. PMID 35988287
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma Cells Through the ceRNA Network.
    Title: LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma Cells Through the ceRNA Network.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23786, FLJ45246, MGC126668, DKFZp686B11107

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 621

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098414.3 → NP_001091884.1  zinc finger protein 621 isoform 1

    See identical proteins and their annotated locations for NP_001091884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC122683, AK127181, BC101619, N51540
    Consensus CDS
    CCDS2693.1
    UniProtKB/Swiss-Prot
    Q14DC7, Q6ZSS3, Q8TE91
    Related
    ENSP00000386051.2, ENST00000403205.6
    Conserved Domains (4) summary
    smart00349
    Location:11 → 71
    KRAB; krueppel associated box
    COG4049
    Location:145 → 198
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:265 → 285
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:221 → 246
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001287245.2 → NP_001274174.1  zinc finger protein 621 isoform 2

    See identical proteins and their annotated locations for NP_001274174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122683, AK074366, N51540
    Consensus CDS
    CCDS74920.1
    UniProtKB/TrEMBL
    C9JM43
    Related
    ENSP00000312144.1, ENST00000310898.5
    Conserved Domains (2) summary
    smart00349
    Location:11 → 71
    KRAB; krueppel associated box
    pfam01352
    Location:11 → 50
    KRAB; KRAB box

  3. NM_198484.5 → NP_940886.1  zinc finger protein 621 isoform 1

    See identical proteins and their annotated locations for NP_940886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC122683, AK127181, N51540
    Consensus CDS
    CCDS2693.1
    UniProtKB/Swiss-Prot
    Q14DC7, Q6ZSS3, Q8TE91
    Related
    ENSP00000340841.5, ENST00000339296.10
    Conserved Domains (4) summary
    smart00349
    Location:11 → 71
    KRAB; krueppel associated box
    COG4049
    Location:145 → 198
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:265 → 285
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:221 → 246
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    40523106..40539782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533610.4 → XP_011531912.1  zinc finger protein 621 isoform X1

    See identical proteins and their annotated locations for XP_011531912.1

    Conserved Domains (3) summary
    COG4049
    Location:137 → 190
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:213 → 238
    zf-H2C2_2; Zinc-finger double domain

  2. XM_005265079.5 → XP_005265136.1  zinc finger protein 621 isoform X1

    See identical proteins and their annotated locations for XP_005265136.1

    Conserved Domains (3) summary
    COG4049
    Location:137 → 190
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:213 → 238
    zf-H2C2_2; Zinc-finger double domain

  3. XM_005265080.5 → XP_005265137.1  zinc finger protein 621 isoform X2

    See identical proteins and their annotated locations for XP_005265137.1

    UniProtKB/TrEMBL
    C9JZC2
    Conserved Domains (3) summary
    COG4049
    Location:110 → 163
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:230 → 250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:186 → 211
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006713114.5 → XP_006713177.1  zinc finger protein 621 isoform X1

    See identical proteins and their annotated locations for XP_006713177.1

    Conserved Domains (3) summary
    COG4049
    Location:137 → 190
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:213 → 238
    zf-H2C2_2; Zinc-finger double domain

  5. XM_017006226.3 → XP_016861715.1  zinc finger protein 621 isoform X2

    UniProtKB/TrEMBL
    C9JZC2
    Conserved Domains (3) summary
    COG4049
    Location:110 → 163
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:230 → 250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:186 → 211
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    40538147..40554832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346294.1 → XP_054202269.1  zinc finger protein 621 isoform X1

  2. XM_054346292.1 → XP_054202267.1  zinc finger protein 621 isoform X1

  3. XM_054346295.1 → XP_054202270.1  zinc finger protein 621 isoform X2

  4. XM_054346293.1 → XP_054202268.1  zinc finger protein 621 isoform X1

  5. XM_054346296.1 → XP_054202271.1  zinc finger protein 621 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZSS3.1 GenPept UniProtKB/Swiss-Prot:Q6ZSS3

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