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GPR42 G protein-coupled receptor 42 [ Homo sapiens (human) ]

Gene ID: 2866, updated on 4-Jan-2025

Summary

Official Symbol
GPR42provided by HGNC
Official Full Name
G protein-coupled receptor 42provided by HGNC
Primary source
HGNC:HGNC:4500
See related
Ensembl:ENSG00000126251 MIM:603822; AllianceGenome:HGNC:4500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FFAR1L; FFAR3L; GPR41L; GPR42P
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See GPR42 in Genome Data Viewer
Location:
19q13.12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35371068..35372962)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37915808..37917703)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35861970..35863864)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3448 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14477 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35843089-35843955 Neighboring gene free fatty acid receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35850683-35851210 Neighboring gene free fatty acid receptor 3 Neighboring gene CRISPRi-validated cis-regulatory element chr19.3689 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51280 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 7 Neighboring gene long intergenic non-protein coding RNA 1531 Neighboring gene RNA, 7SL, cytoplasmic 491, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in plasma membrane  

General protein information

Preferred Names
G-protein coupled receptor 42
Names
G protein-coupled receptor 42 pseudogene
G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348195.2NP_001335124.1  G-protein coupled receptor 42

    Status: VALIDATED

    Source sequence(s)
    AC002511
    Consensus CDS
    CCDS12460.1
    UniProtKB/Swiss-Prot
    O15529
    UniProtKB/TrEMBL
    A0A0K0PUY3, A0A0K0PV74
    Related
    ENSP00000410925.1, ENST00000454971.3
    Conserved Domains (1) summary
    cd15170
    Location:15289
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35371068..35372962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37915808..37917703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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